Abstract
A check list is described which helps the systematic assessment of reports of therapeutic trials, particularly the aspects that need to be considered in assessing their validity. The check list was used to examine 141 reports of therapeutic trials published in four British non-specialist journals in the first six months of 1966 and of 1969. Of these reports 51% were found to be acceptable and a further 16% probably acceptable; 33% were considered unacceptable because they lacked one or more of the features required in a valid report. The check list has been found useful in assessing claims made for drugs and other therapeutic measures on the basis of published reports.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- JOYCE C. R. Patient co-operation and the sensitivity of clinical trials. J Chronic Dis. 1962 Nov;15:1025–1036. doi: 10.1016/0021-9681(62)90123-6. [DOI] [PubMed] [Google Scholar]
- MAHON W. A., DANIEL E. E. A METHOD FOR THE ASSESSMENT OF REPORTS OF DRUG TRIALS. Can Med Assoc J. 1964 Feb 29;90:565–569. [PMC free article] [PubMed] [Google Scholar]
- PATTERSON H. R. Controls in clinical studies. Lancet. 1962 Jan 13;1(7220):90–90. doi: 10.1016/s0140-6736(62)91736-1. [DOI] [PubMed] [Google Scholar]
- Porter A. M. Drug defaulting in a general practice. Br Med J. 1969 Jan 25;1(5638):218–222. doi: 10.1136/bmj.1.5638.218. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reiffenstein R. J., Schiltroth A. J., Todd D. M. Current standards in reported drug trials. Can Med Assoc J. 1968 Dec 14;99(23):1134–1135. [PMC free article] [PubMed] [Google Scholar]