Abstract
Hyperbaric oxygen and the vasodilating effect of tolazoline hydrochloride were used to investigate atherosclerotic ischaemia of the skin of the foot. Ischaemic feet were divided into two subgroups each with a foot blood flow significantly higher than normal and significantly different from each other. The high blood flow in the ischaemic feet appears to have been an attempt to meet a tissue oxygen need. In some instances this need seems to have been satisfied but without obvious benefit to the ischaemic or anoxic skin. It is suggested that a local rather than a regional blood flow insufficiency is the cause of skin lesions in peripheral vascular disease.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ALLWOOD M. J., BURRY H. S. The effect of local temperature on blood flow in the human foot. J Physiol. 1954 May 28;124(2):345–357. doi: 10.1113/jphysiol.1954.sp005112. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CLARKE R. S., HELLON R. F. Venous collection in forearm and hand measured by the strain-gauge and volume plethysmograph. Clin Sci. 1957 Feb;16(1):103–117. [PubMed] [Google Scholar]
- McDowall D. G., Ledingham I. M., Jacobson I., Norman J. N. Oxygen administration by mask in a pressure chamber. Anesthesiology. 1965 Nov-Dec;26(6):720–726. doi: 10.1097/00000542-196511000-00005. [DOI] [PubMed] [Google Scholar]
- Schraibman I. G., Ledingham I. M. Hyperbaric oxygen and local vasodilatation in peripheral vascular disease. Br J Surg. 1969 Apr;56(4):295–299. doi: 10.1002/bjs.1800560414. [DOI] [PubMed] [Google Scholar]
- WHITNEY R. J. The measurement of volume changes in human limbs. J Physiol. 1953 Jul;121(1):1–27. doi: 10.1113/jphysiol.1953.sp004926. [DOI] [PMC free article] [PubMed] [Google Scholar]