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. 1970 Sep 19;3(5724):676–678. doi: 10.1136/bmj.3.5724.676

Protection of Man from Natural Infection with Influenza A2 Hong Kong Virus by Amantadine: A Controlled Field Trial

N Oker-Blom, T Hovi, P Leinikki, T Palosuo, R Pettersson, J Suni
PMCID: PMC1701794  PMID: 4919024

Abstract

Prophylactic administration of amantadine in doses of 100 mg. twice a day offered statistically significant protection against influenza A2 infection in a double-blind field trial involving 391 medical student volunteers during the influenza A2 Hong Kong epidemic in Helsinki in the winter of 1969. Serologically verified influenza, as measured by complement fixation and/or haemagglutination inhibition, occurred in 27 out of 192 students in the amantadine group against 57 out of 199 in the placebo group, giving a protection rate of 52%.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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