Abstract
1. Acid secretion and rate of histamine formation in the gastric mucosa were determined in rats after injection of hog gastrin II, gastrin pentapeptide and some substituted analogues of the C-terminal tetrapeptide of gastrin.
2. Accelerated mucosal histamine formation was induced by hog gastrin II, gastrin pentapeptide and those analogues which elicited acid secretion, whereas secretorily inactive derivatives did not alter histamine formation.
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Selected References
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- ALPHIN R. S., LIN T. M. Preparation of chronic denervated gastric pouches in the rat. Am J Physiol. 1959 Aug;197:257–259. doi: 10.1152/ajplegacy.1959.197.2.257. [DOI] [PubMed] [Google Scholar]
- GREGORY R. A., TRACY H. J. THE CONSTITUTION AND PROPERTIES OF TWO GASTRINS EXTRACTED FROM HOG ANTRAL MUCOSA. Gut. 1964 Apr;5:103–114. [PMC free article] [PubMed] [Google Scholar]
- KAHLSON G., ROSENGREN E., SVAHN D., THUNBERG R. MOBILIZATION AND FORMATION OF HISTAMINE IN THE GASTRIC MUCOSA AS RELATED TO ACID SECRETION. J Physiol. 1964 Nov;174:400–416. doi: 10.1113/jphysiol.1964.sp007494. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KAHLSON G., ROSENGREN E., THUNBERG R. OBSERVATIONS ON THE INHIBITION OF HISTAMINE FORMATION. J Physiol. 1963 Dec;169:467–486. doi: 10.1113/jphysiol.1963.sp007273. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morley J. S. Structure--function relationships in gastrin-like peptides. Proc R Soc Lond B Biol Sci. 1968 May 14;170(1018):97–111. doi: 10.1098/rspb.1968.0028. [DOI] [PubMed] [Google Scholar]
- Morley J. S., Tracy H. J., Gregory R. A. Structure-function relationships in the active C-terminal tetrapeptide sequence of gastrin. Nature. 1965 Sep 25;207(5004):1356–1359. doi: 10.1038/2071356a0. [DOI] [PubMed] [Google Scholar]
- Rosengren E., Svensson S. E. The role of the antrum and the vagus nerve in the formation of gastric mucosal histamine. J Physiol. 1969 Nov;205(2):275–288. doi: 10.1113/jphysiol.1969.sp008964. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TRACY H. J., GREGORY R. A. PHYSIOLOGICAL PROPERTIES OF A SERIES OF SYNTHETIC PEPTIDES STRUCTURALLY RELATED TO GASTRIN I. Nature. 1964 Dec 5;204:935–938. doi: 10.1038/204935a0. [DOI] [PubMed] [Google Scholar]