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. 1970 Apr;38(4):719–724. doi: 10.1111/j.1476-5381.1970.tb09879.x

The effect of betamethasone on circadian and stress-induced pituitary-adrenocortical function in the rat

J R Hodges, Susan Mitchley
PMCID: PMC1702595  PMID: 4315094

Abstract

1. Both the circadian and stress-induced changes in plasma corticosterone concentration were abolished by the inclusion of betamethasone in the drinking water of rats.

2. Adrenal sensitivity to exogenous corticotrophin (ACTH) was unimpaired by the betamethasone treatment.

3. The normal circadian rhythm in plasma corticosterone returned within 1 day of withdrawal of the steroid, but the response to stress was normal only after 3 days.

4. The possible significance of these observations is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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