Abstract
Four of 30 patients with Plasmodium falciparum infection in Bangkok, Thailand, were positive for anti-neutrophil cytoplasmic antibodies by indirect immunofluorescence 1 month after antimalarial therapy. No myeloperoxidase, proteinase 3, lactoferrin, or elastase reactivity was found. Since no evidence of vasculitis was seen in these patients, anti-neutrophil cytoplasmic antibody production in malaria-infected susceptible patients probably represents a secondary response, indicating neutrophil activation.
Full Text
The Full Text of this article is available as a PDF (297.2 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adebajo A. O., Charles P., Maini R. N., Hazleman B. L. Autoantibodies in malaria, tuberculosis and hepatitis B in a west African population. Clin Exp Immunol. 1993 Apr;92(1):73–76. doi: 10.1111/j.1365-2249.1993.tb05950.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Adib-Conquy M., Avrameas S., Ternynck T. Monoclonal IgG and IgM autoantibodies obtained after polyclonal activation, show reactivities similar to those of polyclonal natural autoantibodies. Mol Immunol. 1993 Feb;30(2):119–127. doi: 10.1016/0161-5890(93)90083-n. [DOI] [PubMed] [Google Scholar]
- Berendt A. R., Simmons D. L., Tansey J., Newbold C. I., Marsh K. Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum. Nature. 1989 Sep 7;341(6237):57–59. doi: 10.1038/341057a0. [DOI] [PubMed] [Google Scholar]
- Efthimiou J., Spickett G., Lane D., Thompson A. Antineutrophil cytoplasmic antibodies, cystic fibrosis, and infection. Lancet. 1991 Apr 27;337(8748):1037–1038. doi: 10.1016/0140-6736(91)92694-w. [DOI] [PubMed] [Google Scholar]
- Elkon K. B., Sutherland D. C., Rees A. J., Hughes G. R., Batchelor J. R. HLA antigen frequencies in systemic vasculitis: increase in HLA-DR2 in Wegener's granulomatosis. Arthritis Rheum. 1983 Jan;26(1):102–105. doi: 10.1002/art.1780260118. [DOI] [PubMed] [Google Scholar]
- Falk R. J., Jennette J. C. Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med. 1988 Jun 23;318(25):1651–1657. doi: 10.1056/NEJM198806233182504. [DOI] [PubMed] [Google Scholar]
- Falk R. J., Terrell R. S., Charles L. A., Jennette J. C. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci U S A. 1990 Jun;87(11):4115–4119. doi: 10.1073/pnas.87.11.4115. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Grau G. E., Taylor T. E., Molyneux M. E., Wirima J. J., Vassalli P., Hommel M., Lambert P. H. Tumor necrosis factor and disease severity in children with falciparum malaria. N Engl J Med. 1989 Jun 15;320(24):1586–1591. doi: 10.1056/NEJM198906153202404. [DOI] [PubMed] [Google Scholar]
- Greenwood B. M. Autoimmune disease and parasitic infections in Nigerians. Lancet. 1968 Aug 17;2(7564):380–382. doi: 10.1016/s0140-6736(68)90595-3. [DOI] [PubMed] [Google Scholar]
- Greenwood B. M., Herrick E. M., Holborow E. J. Speckled antinuclear factor in African sera. Clin Exp Immunol. 1970 Jul;7(1):75–83. [PMC free article] [PubMed] [Google Scholar]
- Hagen E. C., Ballieux B. E., van Es L. A., Daha M. R., van der Woude F. J. Antineutrophil cytoplasmic autoantibodies: a review of the antigens involved, the assays, and the clinical and possible pathogenetic consequences. Blood. 1993 Apr 15;81(8):1996–2002. [PubMed] [Google Scholar]
- Kallenberg C. G., Tervaert J. W. Positive ANCA and diagnosis of systemic vasculitis. Clin Nephrol. 1993 Feb;39(2):113–114. [PubMed] [Google Scholar]
- Kern P., Hemmer C. J., Gallati H., Neifer S., Kremsner P., Dietrich M., Porzsolt F. Soluble tumor necrosis factor receptors correlate with parasitemia and disease severity in human malaria. J Infect Dis. 1992 Oct;166(4):930–934. doi: 10.1093/infdis/166.4.930. [DOI] [PubMed] [Google Scholar]
- Mulder A. H., Heeringa P., Brouwer E., Limburg P. C., Kallenberg C. G. Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA): a Fc gamma RII-dependent process. Clin Exp Immunol. 1994 Nov;98(2):270–278. doi: 10.1111/j.1365-2249.1994.tb06137.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ockenhouse C. F., Ho M., Tandon N. N., Van Seventer G. A., Shaw S., White N. J., Jamieson G. A., Chulay J. D., Webster H. K. Molecular basis of sequestration in severe and uncomplicated Plasmodium falciparum malaria: differential adhesion of infected erythrocytes to CD36 and ICAM-1. J Infect Dis. 1991 Jul;164(1):163–169. doi: 10.1093/infdis/164.1.163. [DOI] [PubMed] [Google Scholar]
- Ockenhouse C. F., Tegoshi T., Maeno Y., Benjamin C., Ho M., Kan K. E., Thway Y., Win K., Aikawa M., Lobb R. R. Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1. J Exp Med. 1992 Oct 1;176(4):1183–1189. doi: 10.1084/jem.176.4.1183. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Oquendo P., Hundt E., Lawler J., Seed B. CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Cell. 1989 Jul 14;58(1):95–101. doi: 10.1016/0092-8674(89)90406-6. [DOI] [PubMed] [Google Scholar]
- Phanuphak P., Tirawatnpong S., Hanvanich M., Panmuong W., Moollaor P., Vejjajiva S., Sitprija V., Intaraprasert R., Phanthumkosol D. Autoantibodies in falciparum malaria: a sequential study in 183 Thai patients. Clin Exp Immunol. 1983 Sep;53(3):627–633. [PMC free article] [PubMed] [Google Scholar]
- Pigott R., Dillon L. P., Hemingway I. H., Gearing A. J. Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells. Biochem Biophys Res Commun. 1992 Sep 16;187(2):584–589. doi: 10.1016/0006-291x(92)91234-h. [DOI] [PubMed] [Google Scholar]
- Pudifin D. J., Duursma J., Gathiram V., Jackson T. F. Invasive amoebiasis is associated with the development of anti-neutrophil cytoplasmic antibody. Clin Exp Immunol. 1994 Jul;97(1):48–51. doi: 10.1111/j.1365-2249.1994.tb06578.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rathinaswamy A., Chatur J., Nagvekar U. H., Ramamoorthy N., Desai C. N. Suitability of polyethylene glycol for precipitation of monoclonal antibodies--a radiometric study. Int J Rad Appl Instrum A. 1991;42(2):206–207. doi: 10.1016/0883-2889(91)90076-d. [DOI] [PubMed] [Google Scholar]
- Rosenberg Y. J. Autoimmune and polyclonal B cell responses during murine malaria. Nature. 1978 Jul 13;274(5667):170–172. doi: 10.1038/274170a0. [DOI] [PubMed] [Google Scholar]
- Schmitt W. H., Csernok E., Gross W. L. ANCA and infection. Lancet. 1991 Jun 8;337(8754):1416–1417. doi: 10.1016/0140-6736(91)93102-f. [DOI] [PubMed] [Google Scholar]
- Spencer S. J., Burns A., Gaskin G., Pusey C. D., Rees A. J. HLA class II specificities in vasculitis with antibodies to neutrophil cytoplasmic antigens. Kidney Int. 1992 Apr;41(4):1059–1063. doi: 10.1038/ki.1992.161. [DOI] [PubMed] [Google Scholar]
- Tervaert J. W., Goldschmeding R., Elema J. D., Limburg P. C., van der Giessen M., Huitema M. G., Koolen M. I., Hené R. J., The T. H., van der Hem G. K. Association of autoantibodies to myeloperoxidase with different forms of vasculitis. Arthritis Rheum. 1990 Aug;33(8):1264–1272. doi: 10.1002/art.1780330829. [DOI] [PubMed] [Google Scholar]
- Tervaert J. W., Goldschmeding R., Elema J. D., van der Giessen M., Huitema M. G., van der Hem G. K., The T. H., von dem Borne A. E., Kallenberg C. G. Autoantibodies against myeloid lysosomal enzymes in crescentic glomerulonephritis. Kidney Int. 1990 Feb;37(2):799–806. doi: 10.1038/ki.1990.48. [DOI] [PubMed] [Google Scholar]
- Thorp K. M., Southern C., Bird I. N., Matthews N. Tumour necrosis factor induction of ELAM-1 and ICAM-1 on human umbilical vein endothelial cells--analysis of tumour necrosis factor-receptor interactions. Cytokine. 1992 Jul;4(4):313–319. doi: 10.1016/1043-4666(92)90072-y. [DOI] [PubMed] [Google Scholar]
- Wenisch C., Graninger W. Are soluble factors relevant for polymorphonuclear leukocyte dysregulation in septicemia? Clin Diagn Lab Immunol. 1995 Mar;2(2):241–245. doi: 10.1128/cdli.2.2.241-245.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wenisch C., Looareesuwan S., Parschalk B., Graninger W. Soluble vascular cell adhesion molecule 1 is elevated in patients with Plasmodium falciparum malaria. J Infect Dis. 1994 Mar;169(3):710–711. doi: 10.1093/infdis/169.3.710. [DOI] [PubMed] [Google Scholar]
- Wenisch C., Varijanonta S., Looareesuwan S., Graninger W., Pichler R., Wernsdorfer W. Soluble intercellular adhesion molecule-1 (ICAM-1), endothelial leukocyte adhesion molecule-1 (ELAM-1), and tumor necrosis factor receptor (55 kDa TNF-R) in patients with acute Plasmodium falciparum malaria. Clin Immunol Immunopathol. 1994 Jun;71(3):344–348. doi: 10.1006/clin.1994.1096. [DOI] [PubMed] [Google Scholar]
- Wyler D. J. Cellular aspects of immunoregulation in malaria. Bull World Health Organ. 1979;57 (Suppl 1):239–243. [PMC free article] [PubMed] [Google Scholar]