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. 1970 Apr;38(4):802–809. doi: 10.1111/j.1476-5381.1970.tb09889.x

An ultrastructural and histochemical study of the short-term effects of 6-hydroxydopamine on adrenergic nerves in the domestic fowl

T Bennett, G Burnstock, J L S Cobb, T Malmfors
PMCID: PMC1702600  PMID: 5441792

Abstract

1. The effects of 6-hydroxydopamine (6-OHDA) on adrenergic nerves in the domestic fowl have been investigated with ultrastructural and fluorescence histochemical methods.

2. 6-OHDA depletes the nerves of catecholamine, initially by displacing it from the storage vesicles. 6-OHDA enters large as well as small vesicles, indicating that large granular vesicles in adrenergic nerves are sites of amine storage.

3. Doses of 6-OHDA, insufficient to cause degeneration, still cause loading of the vesicles.

4. The effects of various drugs on the action of 6-OHDA indicate that this drug must be taken up by the nerves and reach a critical extragranular axoplasmic concentration before degeneration will occur; 6-OHDA bound in the vesicles plays no part in the degenerative process.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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