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. 1970 Sep;40(1):86–91. doi: 10.1111/j.1476-5381.1970.tb10613.x

Effects of morphine and pentobarbitone on acetylcholine synthesis by rat cerebral cortex

M Sharkawi
PMCID: PMC1702673  PMID: 4321081

Abstract

1. The synthesis of carbon-14-labelled acetylcholine (14C-ACh) from carbon-14 uniformly labelled glucose (U-14C-D-glucose) under different conditions was studied.

2. The ability of cerebral cortex slices and minces from morphine-treated and pentobarbitone-treated rats incubated in 4 mM K+ medium to form 14C-ACh was markedly reduced as compared with those from control animals.

3. The ability of slices from drug-treated and control animals incubated in 31 mM K+ medium to form 14C-ACh was similar.

4. Cerebral cortex homogenates from both groups of animals in either 4 or 31 mM K+ medium formed similar amounts of 14C-ACh.

5. These findings add further support to the hypothesis that the concentration of ACh at the site of synthesis governs the rate of formation of the neurotransmitter.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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