Abstract
1. The effects of vagotomy on the respiratory responses of guinea-pigs to anaphylactic reactions and to intravenous injections of histamine acid phosphate are described.
2. In spontaneously breathing guinea-pigs, vagotomy reduced by 50% or more the decreases in total lung conductance (bronchoconstriction) and the decreases in lung compliance, and almost abolished the rapid shallow breathing due to histamine.
3. In paralysed, artificially ventilated guinea-pigs, vagotomy reduced by more than 33% the decreases in total lung conductance, but had little effect on the changes in lung compliance due to histamine.
4. In paralysed, artificially ventilated guinea-pigs, vagotomy reduced by 75% the decrease in total lung conductance and halved the decrease in lung compliance due to anaphylaxis.
5. We conclude that a vagal reflex is mainly responsible for the rapid shallow breathing due to histamine, and partly responsible for the bronchoconstrictions due to histamine and to anaphylaxis in guinea-pigs. We suggest that “lung irritant receptors” in the bronchial epithelium are the afferent end-organs involved.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BOUHUYS A., JONSSON R., LIGHTNECKERT S., LINDELL S. E., LUNDGREN C., LUNDIN G., RINGQUIST T. R. Effects of histamine on pulmonary ventilation in man. Clin Sci. 1960 Feb;19:79–94. [PubMed] [Google Scholar]
- COLLIER H. O., HOLGATE J. A., SCHACHTER M., SHORLEY P. G. The bronchoconstrictor action of bradykinin in the guinea-pig. Br J Pharmacol Chemother. 1960 Jun;15:290–297. doi: 10.1111/j.1476-5381.1960.tb01247.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DeKock M. A., Nadel J. A., Zwi S., Colebatch H. J., Olsen C. R. New method for perfusing bronchial arteries: histamine bronchoconstriction and apnea. J Appl Physiol. 1966 Jan;21(1):185–194. doi: 10.1152/jappl.1966.21.1.185. [DOI] [PubMed] [Google Scholar]
- Homberger A. C. Beitrag zum Nachweis von Kollapsafferenzen im Lungenvagus des Kaninchens. Helv Physiol Pharmacol Acta. 1968;26(1):97–118. [PubMed] [Google Scholar]
- Karczewski W., Widdicombe J. G. The role of the vagus nerves in the respiratory and circulatory reactions to anaphylaxis in rabbits. J Physiol. 1969 Apr;201(2):293–304. doi: 10.1113/jphysiol.1969.sp008756. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karczewski W., Widdicombe J. G. The role of the vagus nerves in the respiratory and circulatory responses to intravenous histamine and phenyl diguanide in rabbits. J Physiol. 1969 Apr;201(2):271–291. doi: 10.1113/jphysiol.1969.sp008755. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Koller E. A. Atmung und Kreislauf im anaphylaktischen Asthma bronchiale des Meerschweinchens I. Atmungs-und Kreislaufreaktionen des "Normaltieres". Helv Physiol Pharmacol Acta. 1967;25(3):287–308. [PubMed] [Google Scholar]
- Koller E. A. Atmung und Kreislauf im anaphylaktischen Asthma bronchiale des Meerschweinchens. 3. Die Lungenveränderungen im Asthmaanfall und die inspiratorische Reaktion. Helv Physiol Pharmacol Acta. 1968;26(2):153–170. [PubMed] [Google Scholar]
- MARTINEZ DE LETONA J., CASTRO DE LA MATA R., AVIADO D. M. Local and reflex effect of bronchial arterial injection of drugs. J Pharmacol Exp Ther. 1961 Sep;133:295–303. [PubMed] [Google Scholar]
- MONGAR J. L., SCHILD H. O. Cellular mechanisms in anaphylaxis. Physiol Rev. 1962 Apr;42:226–270. doi: 10.1152/physrev.1962.42.2.226. [DOI] [PubMed] [Google Scholar]
- Mills J. E., Sellick H., Widdicombe J. G. Activity of lung irritant receptors in pulmonary microembolism, anaphylaxis and drug-induced bronchoconstrictions. J Physiol. 1969 Aug;203(2):337–357. doi: 10.1113/jphysiol.1969.sp008867. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sellick H., Widdicombe J. G. The activity of lung irritant receptors during pneumothorax, hyperpnoea and pulmonary vascular congestion. J Physiol. 1969 Aug;203(2):359–381. doi: 10.1113/jphysiol.1969.sp008868. [DOI] [PMC free article] [PubMed] [Google Scholar]