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. 1971 Jan;41(1):49–56. doi: 10.1111/j.1476-5381.1971.tb09934.x

Cutaneous reactions to intradermal prostaglandins

Pearl Crunkhorn, A L Willis
PMCID: PMC1702738  PMID: 4396130

Abstract

1. The effects of intradermally injected prostaglandins (PGs) E1, E2, F1α and F2α have been examined in the rat and in man.

2. PGE1 and PGE2 caused an increase in local vascular permeability in rat skin; their potency was comparable with that of other putative mediators of inflammation (histamine, bradykinin, and 5-hydroxytryptamine), but PGF1α and PGF2α were only slightly active even at a dose of 1 μg.

3. Prior administration of mepyramine and methysergide, or depletion of skin mast cell amines with compound 48/80, indicated that PGE2 exerted its permeability effect in the rat by a release of mast cell amines.

4. Nanogramme doses of PGE1 and PGE2 or microgramme doses of PGF1α and PGF2α injected intradermally into the human forearm induced weal and flare responses.

5. It is concluded that prostaglandins E1 and E2 can act as intermediates in the production of hyperaemia and oedema resulting from cell damage in the rat and man.

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54FIG. 3.
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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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