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. 1971 Jan;41(1):122–131. doi: 10.1111/j.1476-5381.1971.tb09942.x

Effect of β-adrenoceptive blocking agents on the response to bronchoconstrictor drugs in the guinea-pig air overflow preparation

D T Burden, M W Parkes, D G Gardiner
PMCID: PMC1702742  PMID: 4396128

Abstract

1. Propranolol augmented the bronchoconstrictor response to methacholine or histamine, recorded by air overflow in the anaesthetized, vagotomized guinea-pig.

2. After adrenalectomy, propranolol was still active, though less so than before.

3. In the pithed guinea-pig, there was no augmentation of the effect of bronchoconstrictors on air overflow. The action of propranolol could thus be due to the β-adrenoceptor blockade of compensatory sympathetic bronchodilator activity, as concluded by McCulloch, Proctor & Rand (1967).

4. Electrical stimulation of the thoracic region of the spinal cord of the pithed guinea-pig reduced the effect of bronchoconstrictors on air overflow. This reduction could be blocked by propranolol; practolol was much less effective.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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