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. 1971 Apr;41(4):592–599. doi: 10.1111/j.1476-5381.1971.tb07067.x

Cardiovascular actions of substituted adenosine analogues

J A Angus, L B Cobbin, Rosemarie Einstein, M H Maguire
PMCID: PMC1702762  PMID: 5579459

Abstract

1. The effects of adenosine on systemic blood pressure, coronary blood flow and cardiac contractility and rate were studied in anaesthetized open-thorax dogs.

2. The potency and duration of action of substituted adenosine analogues were compared with that of adenosine.

3. With the exception of 2-chloroadenosine, in which coronary dilator activity was enhanced, substitution in the 2-position of the adenosine molecule reduced activity.

4. In all cases 2-substitution prolonged the duration of the coronary dilator activity of adenosine.

5. N6-Methylation of adenosine and 2-chloroadenosine reduced their coronary dilator activities, but had no effect on the duration of the response.

6. Comparison of the coronary dilator potencies and hypotensive activities of 2-ethylaminoadenosine and 2-methoxyadenosine indicates that these analogues have some specificity for the coronary bed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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