Skip to main content
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1971 Apr;41(4):571–591. doi: 10.1111/j.1476-5381.1971.tb07066.x

Role of transmitter uptake mechanisms in synaptic neurotransmission.

L L Iversen
PMCID: PMC1702772  PMID: 4397129

Full text

PDF
571

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AXELROD J., WEIL-MALHERBE H., TOMCHICK R. The physiological disposition of H3-epinephrine and its metabolite metanephrine. J Pharmacol Exp Ther. 1959 Dec;127:251–256. [PubMed] [Google Scholar]
  2. Aprison M. H., Werman R. The distribution of glycine in cat spinal cord and roots. Life Sci. 1965 Nov;4(21):2075–2083. doi: 10.1016/0024-3205(65)90325-5. [DOI] [PubMed] [Google Scholar]
  3. Avakian O. V., Gillespie J. S. Uptake of noradrenaline by adrenergic nerves, smooth muscle and connective tissue in isolated perfused arteries and its correlation with the vasoconstrictor response. Br J Pharmacol Chemother. 1968 Jan;32(1):168–184. doi: 10.1111/j.1476-5381.1968.tb00441.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Axelrod J., Kopin I. J. The uptake, storage, release and metabolism of noradrenaline in sympathetic nerves. Prog Brain Res. 1969;31:21–32. doi: 10.1016/S0079-6123(08)63224-0. [DOI] [PubMed] [Google Scholar]
  5. BORN G. V., GILLSON R. E. Studies on the uptake of 5-hydroxytryptamine by blood platelets. J Physiol. 1959 Jun 11;146(3):472–491. doi: 10.1113/jphysiol.1959.sp006206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BROWN G. L., GILLESPIE J. S. The output of sympathetic transmitter from the spleen of the cat. J Physiol. 1957 Aug 29;138(1):81–102. doi: 10.1113/jphysiol.1957.sp005839. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Blackburn K. J., French P. C., Merrills R. J. 5-hydroxytryptamine uptake by rat brain in vitro. Life Sci. 1967 Aug 1;6(15):1653–1663. doi: 10.1016/0024-3205(67)90176-2. [DOI] [PubMed] [Google Scholar]
  8. Callingham B. A., Burgen A. S. The uptake of isoprenaline and noradrenaline by the perfused rat heart. Mol Pharmacol. 1966 Jan;2(1):37–42. [PubMed] [Google Scholar]
  9. Chase T. N., Breese G. R., Carpenter D. O., Schanberg S. M., Kopin I. J. Stimulation-induced release of serotonin. Adv Pharmacol. 1968;6(Pt A):351–364. doi: 10.1016/s1054-3589(08)61191-6. [DOI] [PubMed] [Google Scholar]
  10. Clarke D. E., Jones C. J., Linley P. A. Histochemical fluorescence studies on noradrenaline accumulation by Uptake 2 in the isolated rat heart. Br J Pharmacol. 1969 Sep;37(1):1–9. doi: 10.1111/j.1476-5381.1969.tb09515.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Colburn R. W., Goodwin F. K., Murphy D. L., Bunney W. E., Jr, Davis J. M. Quantitative studies of norepinephrine uptake by synaptosomes. Biochem Pharmacol. 1968 Jun;17(6):957–964. doi: 10.1016/0006-2952(68)90354-7. [DOI] [PubMed] [Google Scholar]
  12. Coyle J. T., Snyder S. H. Antiparkinsonian drugs: inhibition of dopamine uptake in the corpus striatum as a possible mechanism of action. Science. 1969 Nov 14;166(3907):899–901. doi: 10.1126/science.166.3907.899. [DOI] [PubMed] [Google Scholar]
  13. Coyle J. T., Snyder S. H. Catecholamine uptake by synaptosomes in homogenates of rat brain: stereospecificity in different areas. J Pharmacol Exp Ther. 1969 Dec;170(2):221–231. [PubMed] [Google Scholar]
  14. Curtis D. R., Crawford J. M. Central synaptic transmission--microelectrophoretic studies. Annu Rev Pharmacol. 1969;9:209–240. doi: 10.1146/annurev.pa.09.040169.001233. [DOI] [PubMed] [Google Scholar]
  15. Curtis D. R., Hösli L., Johnston G. A. A pharmacological study of the depression of spinal neurones by glycine and related amino acids. Exp Brain Res. 1968;6(1):1–18. doi: 10.1007/BF00235443. [DOI] [PubMed] [Google Scholar]
  16. Curtis D. R. The pharmacology of spinal postsynaptic inhibition. Prog Brain Res. 1969;31:171–189. doi: 10.1016/s0079-6123(08)63237-9. [DOI] [PubMed] [Google Scholar]
  17. Curtis D. R., Watkins J. C. The pharmacology of amino acids related to gamma-aminobutyric acid. Pharmacol Rev. 1965 Dec;17(4):347–391. [PubMed] [Google Scholar]
  18. Douglas W. W. Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. Br J Pharmacol. 1968 Nov;34(3):451–474. doi: 10.1111/j.1476-5381.1968.tb08474.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Draskóczy P. R., Trendelenburg U. Intraneuronal and extraneuronal accumulation of sympathomimetic amines in the isolated nictitating membrane of the cat. J Pharmacol Exp Ther. 1970 Aug;174(2):290–306. [PubMed] [Google Scholar]
  20. Draskóczy P. R., Trendelenburg U. The uptake of l- and d-norepinephrine by the isolated perfused rabbit heart in relation to the stereospecificity of the sensitizing action of cocaine. J Pharmacol Exp Ther. 1968 Jan;159(1):66–73. [PubMed] [Google Scholar]
  21. Farnebo L. O., Malmfors T. Histochemical studies on the uptake of noradrenaline and alpha-methyl-noradrenaline in the perfused rat heart. Eur J Pharmacol. 1969 Mar;5(4):313–320. doi: 10.1016/0014-2999(69)90107-1. [DOI] [PubMed] [Google Scholar]
  22. Ferry C. B. The autonomic nervous system. Annu Rev Pharmacol. 1967;7:185–202. doi: 10.1146/annurev.pa.07.040167.001153. [DOI] [PubMed] [Google Scholar]
  23. Foster R. W. An uptake of radioactivity from (plus or minus)-3H-isoprenaline and its inhibition by drugs which potentiate the responses to (minus)-isoprenaline in the guinea-pig isolated trachea. Br J Pharmacol. 1969 Mar;35(3):418–427. doi: 10.1111/j.1476-5381.1969.tb08283.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. GADDUM J. H., HOLZBAUER M. Adrenaline and noradrenaline. Vitam Horm. 1957;15:151–203. doi: 10.1016/s0083-6729(08)60510-5. [DOI] [PubMed] [Google Scholar]
  25. GADDUM J. H., LEMBECK F. The assay of substances from the adrenal medulla. Br J Pharmacol Chemother. 1949 Dec;4(4):401–408. doi: 10.1111/j.1476-5381.1949.tb00566.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. GADDUM J. H., PAASONEN M. K. The use of some molluscan hearts for the estimation of 5-hydroxytryptamine. Br J Pharmacol Chemother. 1955 Dec;10(4):474–483. doi: 10.1111/j.1476-5381.1955.tb00108.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Gaddum J. H., Goodwin L. G. Experiments on liver sympathin. J Physiol. 1947 Jan 15;105(4):357–369. [PMC free article] [PubMed] [Google Scholar]
  28. Gaddum J. H., Jang C. S., Kwiatkowski H. The effect on the intestine of the substance liberated by adrenergic nerves in a rabbit's ear. J Physiol. 1939 Jun 14;96(1):104–108. doi: 10.1113/jphysiol.1939.sp003760. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Gaddum J. H., Kwiatkowski H. The action of ephedrine. J Physiol. 1938 Oct 14;94(1):87–100. doi: 10.1113/jphysiol.1938.sp003664. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Gaddum J. H., Peart W. S., Vogt M. The estimation of adrenaline and allied substances in blood. J Physiol. 1949 Jun 15;108(4):467–481. doi: 10.1113/jphysiol.1949.sp004350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Gerschenfeld H. M., Stefani E. Evidence for an excitatory transmitter role of serotonin in molluscan central synapses. Adv Pharmacol. 1968;6(Pt A):369–392. doi: 10.1016/s1054-3589(08)61193-x. [DOI] [PubMed] [Google Scholar]
  32. Gillespie J. S., Hamilton D. N., Hosie J. A. The extraneuronal uptake and localization of noradrenaline in the cat spleen and the effect on this of some drugs, of cold and of denervation. J Physiol. 1970 Mar;206(3):563–590. doi: 10.1113/jphysiol.1970.sp009031. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Gillespie J. S., Muir T. C. Species and tissue variation in extraneuronal and neuronal accumulation of noradrenaline. J Physiol. 1970 Mar;206(3):591–604. doi: 10.1113/jphysiol.1970.sp009032. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Glowinski J., Baldessarini R. J. Metabolism of norepinephrine in the central nervous system. Pharmacol Rev. 1966 Dec;18(4):1201–1238. [PubMed] [Google Scholar]
  35. Hebb C. CNS at the cellular level: identity of transmitter agents. Annu Rev Physiol. 1970;32:165–192. doi: 10.1146/annurev.ph.32.030170.001121. [DOI] [PubMed] [Google Scholar]
  36. Hertting G., Suko J., Widhalm S., Harbich I. Uber den Mechanismus der Potenzierung der KKatecholaminwirkung nach chronisch postganglionärer sympathischer Denervierung. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1967;256(1):40–54. [PubMed] [Google Scholar]
  37. IVERSEN L. L. THE UPTAKE OF NORADRENALINE BY THE ISOLATED PERFUSED RAT HEART. Br J Pharmacol Chemother. 1963 Dec;21:523–537. doi: 10.1111/j.1476-5381.1963.tb02020.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. IVERSEN L. L., WHITBY L. G. Retention of injected catechol amines by the mouse. Br J Pharmacol Chemother. 1962 Oct;19:355–364. doi: 10.1111/j.1476-5381.1962.tb01199.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Iversen L. L. Accumulation of alpha-methyltyramine by the noradrenaline uptake process in the isolated rat heart. J Pharm Pharmacol. 1966 Aug;18(8):481–484. doi: 10.1111/j.2042-7158.1966.tb07914.x. [DOI] [PubMed] [Google Scholar]
  40. Iversen L. L., Glowinski J., Axelrod J. The physiologic disposition and metabolism of norepinephrine in immunosympathectomized animals. J Pharmacol Exp Ther. 1966 Feb;151(2):273–284. [PubMed] [Google Scholar]
  41. Iversen L. L., Kravitz E. A. The metabolism of gamma-aminobutyric acid (GABA) in the lobster nervous system--uptake of GABA in the nerve-muscle preparations. J Neurochem. 1968 Jul;15(7):609–620. doi: 10.1111/j.1471-4159.1968.tb08960.x. [DOI] [PubMed] [Google Scholar]
  42. Iversen L. L., Neal M. J. The uptake of [3H]GABA by slices of rat cerebral cortex. J Neurochem. 1968 Oct;15(10):1141–1149. doi: 10.1111/j.1471-4159.1968.tb06831.x. [DOI] [PubMed] [Google Scholar]
  43. Iversen L. L., Salt P. J. Inhibition of catecholamine Uptake-2 by steroids in the isolated rat heart. Br J Pharmacol. 1970 Nov;40(3):528–530. doi: 10.1111/j.1476-5381.1970.tb10637.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Jonsson G., Sachs C. Effects of 6-hydroxydopamine on the uptake and storage of noradrenaline in sympathetic adrenergic neurons. Eur J Pharmacol. 1970 Feb;9(2):141–155. doi: 10.1016/0014-2999(70)90293-1. [DOI] [PubMed] [Google Scholar]
  45. KIRPEKAR S. M., CERVONI P. EFFECT OF COCAINE, PHENOXYBENZAMINE AND PHENTOLAMINE ON THE CATECHOLAMINE OUTPUT FROM SPLEEN AND ADRENAL MEDULLA. J Pharmacol Exp Ther. 1963 Oct;142:59–70. [PubMed] [Google Scholar]
  46. Kalsner S. Mechanism of hydrocortisone potentiation of responses to epinephrine and norepinephrine in rabbit aorta. Circ Res. 1969 Mar;24(3):383–395. doi: 10.1161/01.res.24.3.383. [DOI] [PubMed] [Google Scholar]
  47. Kalsner S. Steroid potentiation of responses to sympathomimetic amines in aortic strips. Br J Pharmacol. 1969 Jul;36(3):582–593. doi: 10.1111/j.1476-5381.1969.tb08013.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Kopin I. J. False adrenergic transmitters. Annu Rev Pharmacol. 1968;8:377–394. doi: 10.1146/annurev.pa.08.040168.002113. [DOI] [PubMed] [Google Scholar]
  49. Krnjević K. Glutamate and gamma-aminobutyric acid in brain. Nature. 1970 Oct 10;228(5267):119–124. doi: 10.1038/228119a0. [DOI] [PubMed] [Google Scholar]
  50. Langer S. Z., Draskóczy P. R., Trendelenburg U. Time course of the development of supersensitivity to various amines in the nictitating membrane of the pithed cat after denervation or decentralization. J Pharmacol Exp Ther. 1967 Aug;157(2):255–273. [PubMed] [Google Scholar]
  51. Langer S. Z. The metabolism of (3H)noradrenaline released by electrical stimulation from the isolated nictitating membrane of the cat and from the vas deferens of the rat. J Physiol. 1970 Jul;208(3):515–546. doi: 10.1113/jphysiol.1970.sp009135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Langer S. Z., Trendelenburg U. The effect of a saturable uptake mechanism on the slopes of dose-response curves for sympathomimetic amines and on the shifts of dose-response curves produced by a competitive antagonist. J Pharmacol Exp Ther. 1969 May;167(1):117–142. [PubMed] [Google Scholar]
  53. Liang C. C., Quastel J. H. Uptake of acetylcholine in rat brain cortex slices. Biochem Pharmacol. 1969 May;18(5):1169–1185. doi: 10.1016/0006-2952(69)90120-8. [DOI] [PubMed] [Google Scholar]
  54. Lightman S. L., Iversen L. L. The role of uptake2 in the extraneuronal metabolism of catecholamines in the isolated rat heart. Br J Pharmacol. 1969 Nov;37(3):638–649. doi: 10.1111/j.1476-5381.1969.tb08502.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Marchbanks R. M. The uptake of [14C] choline into synaptosomes in vitro. Biochem J. 1968 Dec;110(3):533–541. doi: 10.1042/bj1100533. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Muscholl E. Autonomic nervous system: newer mechanisms of adrenergic blockade. Annu Rev Pharmacol. 1966;6:107–128. doi: 10.1146/annurev.pa.06.040166.000543. [DOI] [PubMed] [Google Scholar]
  57. Neal M. J., Iversen L. L. Subcellular distribution of endogenous and (3H) gamma-aminobutyric acid in rat cerebral cortex. J Neurochem. 1969 Aug;16(8):1245–1252. doi: 10.1111/j.1471-4159.1969.tb05972.x. [DOI] [PubMed] [Google Scholar]
  58. Neal M. J., Pickles H. G. Uptake of 14C glycine by spinal cord. Nature. 1969 May 17;222(5194):679–680. doi: 10.1038/222679a0. [DOI] [PubMed] [Google Scholar]
  59. Otsuka M., Iversen L. L., Hall Z. W., Kravitz E. A. Release of gamma-aminobutyric acid from inhibitory nerves of lobster. Proc Natl Acad Sci U S A. 1966 Oct;56(4):1110–1115. doi: 10.1073/pnas.56.4.1110. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Pletscher A. Metabolism, transfer and storage of 5-hydroxytryptamine in blood platelets. Br J Pharmacol Chemother. 1968 Jan;32(1):1–16. doi: 10.1111/j.1476-5381.1968.tb00423.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Ross S. B., Renyl A. L. Accumulation of tritiated 5-hydroxytryptamine in brain slices. Life Sci. 1967 Jul 1;6(13):1407–1415. doi: 10.1016/0024-3205(67)90188-9. [DOI] [PubMed] [Google Scholar]
  62. SCHAYER R. W. A UNIFIED THEORY OF GLUCOCORTICOID ACTION. Perspect Biol Med. 1964;7:71–84. doi: 10.1353/pbm.1964.0006. [DOI] [PubMed] [Google Scholar]
  63. SISKEN B., ROBERTS E. RADIOAUTOGRAPHIC STUDIES OF BINDING OF GAMMA-AMINOBUTYRIC ACID TO THE ABDOMINAL STRETCH RECEPTORS OF THE CRAYFISH. Biochem Pharmacol. 1964 Jan;13:95–103. doi: 10.1016/0006-2952(64)90083-8. [DOI] [PubMed] [Google Scholar]
  64. Shaskan E. G., Snyder S. H. Kinetics of serotonin accumulation into slices from rat brain: relationship to catecholamine uptake. J Pharmacol Exp Ther. 1970 Nov;175(2):404–418. [PubMed] [Google Scholar]
  65. Sneddon J. M. Sodium-dependent accumulation of 5-hydroxytryptamine by rat blood platelets. Br J Pharmacol. 1969 Nov;37(3):680–688. doi: 10.1111/j.1476-5381.1969.tb08506.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Snyder S. H., Coyle J. T. Regional differences in H3-norepinephrine and H3-dopamine uptake into rat brain homogenates. J Pharmacol Exp Ther. 1969 Jan;165(1):78–86. [PubMed] [Google Scholar]
  67. Strasberg P., Elliott K. A. Further studies on the binding of gamma-aminobutyric acid by brain. Can J Biochem. 1967 Dec;45(12):1795–1807. doi: 10.1139/o67-213. [DOI] [PubMed] [Google Scholar]
  68. THOENEN H., HUERLIMANN A., HAEFELY W. THE EFFECT OF SYMPATHETIC NERVE STIMULATION ON VOLUME, VASCULAR RESISTANCE, AND NOREPINEPHRINE OUTPUT IN THE ISOLATED PERFUSED SPLEEN OF THE CAT, AND ITS MODIFICATION BY COCAINE. J Pharmacol Exp Ther. 1964 Jan;143:57–63. [PubMed] [Google Scholar]
  69. THOENEN H., HUERLIMANN A., HAEFELY W. WIRKUNGEN VON PHENOXYBENZAMIN, PHENTOLAMIN UND AZAPETIN AUF ADRENERGISCHE SYNAPSEN DER KATZENMILZ. BLOCKIERUNG DER ALPHA-ADRENERGISCHEN REZEPTOREN UND HEMMUNG DER WIEDERAUFNAHME VON NEURAL FREIGESETZTEM NORADRENALIN. Helv Physiol Pharmacol Acta. 1964;22:148–161. [PubMed] [Google Scholar]
  70. Thoenen H., Hürlimann A., Haefely W. Mechanism of amphetamine accumulation in the isolated perfused heart of the rat. J Pharm Pharmacol. 1968 Jan;20(1):1–11. doi: 10.1111/j.2042-7158.1968.tb09611.x. [DOI] [PubMed] [Google Scholar]
  71. Thoenen H., Tranzer J. P. Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-Hydroxydopamine. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1968;261(3):271–288. doi: 10.1007/BF00536990. [DOI] [PubMed] [Google Scholar]
  72. Todrick A., Tait A. C. The inhibition of human platelet 5-hydroxytryptamine uptake by tricyclic antidepressive drugs. The relation between structure and potency. J Pharm Pharmacol. 1969 Nov;21(11):751–762. doi: 10.1111/j.2042-7158.1969.tb08164.x. [DOI] [PubMed] [Google Scholar]
  73. Tranzer J. P., Thoenen H. Electronmicroscopic localization of 5-hydroxydopamine (3,4,5-trihydroxy-phenyl-ethylamine), a new 'false' sympathetic transmitter. Experientia. 1967 Sep 15;23(9):743–745. doi: 10.1007/BF02154151. [DOI] [PubMed] [Google Scholar]
  74. Trendelenburg U., Draskóczy P. R., Pluchino S. The density of adrenergic innervation of the cat's nictitating membrane as a factor influencing the sensitivity of the isolated preparation to l-norepinephrine. J Pharmacol Exp Ther. 1969 Mar;166(1):14–25. [PubMed] [Google Scholar]
  75. Trendelenburg U. Mechanisms of supersensitivity and subsensitivity to sympathomimetic amines. Pharmacol Rev. 1966 Mar;18(1):629–640. [PubMed] [Google Scholar]
  76. Uretsky N. J., Iversen L. L. Effects of 6-hydroxydopamine on catecholamine containing neurones in the rat brain. J Neurochem. 1970 Feb;17(2):269–278. doi: 10.1111/j.1471-4159.1970.tb02210.x. [DOI] [PubMed] [Google Scholar]
  77. Vane J. R. The release and fate of vaso-active hormones in the circulation. Br J Pharmacol. 1969 Feb;35(2):209–242. doi: 10.1111/j.1476-5381.1969.tb07982.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  78. WEINSTEIN H., VARON S., MUHLEMAN D. R., ROBERTS E. A CARRIER-MEDIATED TRANSFER MODEL FOR THE ACCUMULATION OF 14-C-GAMMA-AMINOBUTYRIC ACID BY SUBCELLULAR BRAIN PARTICLES. Biochem Pharmacol. 1965 Mar;14:273–288. doi: 10.1016/0006-2952(65)90192-9. [DOI] [PubMed] [Google Scholar]
  79. WELSH J. H. Serotonin as a possible neurohumoral agent; evidence obtained in lower animals. Ann N Y Acad Sci. 1957 Mar 14;66(3):618–630. doi: 10.1111/j.1749-6632.1957.tb40752.x. [DOI] [PubMed] [Google Scholar]
  80. WHITBY L. G., AXELROD J., WEIL-MALHERBE H. The fate of H3-norepinephrine in animals. J Pharmacol Exp Ther. 1961 May;132:193–201. [PubMed] [Google Scholar]
  81. Werman R., Davidoff R. A., Aprison M. H. Inhibition of motoneurones by iontophoresis of glycine. Nature. 1967 May 13;214(5089):681–683. doi: 10.1038/214681a0. [DOI] [PubMed] [Google Scholar]
  82. White T. D., Keen P. The role of internal and external Na+ and K+ on the uptake of [3H] noradrenaline by synaptosomes prepared from rat brain. Biochim Biophys Acta. 1970;196(2):285–295. doi: 10.1016/0005-2736(70)90016-7. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES