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. 1970 Feb;38(2):366–373. doi: 10.1111/j.1476-5381.1970.tb08524.x

Pharmacological significance of biogenic amines in the lungs

Histamine

Domingo M Aviado, Chiravat Sadavongvivad
PMCID: PMC1702811  PMID: 5417859

Abstract

1. Eight animal species were investigated for the histamine content of the lung and can be divided into two groups: the low-level group, ranging from 2 to 7 μg/g, consisting of the mouse, rat, guinea-pig and rabbit; and the high-level group, ranging from 12 to 35 μg/g, consisting of the cat, dog, goat and human. In two species of the high-level group (cat and dog) the amount of histamine that elicited an increase in pulmonary resistance was one-fifth to one-tenth of the dose that elicited an increase in species of the low-level group (rat and rabbit). There is an inverse relationship between the content of histamine and the dose of histamine that produces a 25% increase in pulmonary resistance.

2. Anaphylaxis increases the histamine content of the lung of the rabbit but not of the lung of the guinea-pig. In both species, anaphylaxis is accompanied by an elevation of the concentration of 5-hydroxytryptamine in the lung, indicating the trapping of platelets in the lung.

3. The development of severe parasitaemia in the mouse inoculated with Plasmodium berghei is accompanied by an elevation of the histamine content of the lung. This increase appears to be part of the response of the lung to parasitaemia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AGARWAL S. L., DESHMANKAR B. S., BHARGAVA V. CHLOROQUINE IN BRONCHIAL ASTHMA. J Pharm Pharmacol. 1963 Oct;15:693–693. doi: 10.1111/j.2042-7158.1963.tb12862.x. [DOI] [PubMed] [Google Scholar]
  2. AVIADO D. M. Therapy of experimental pulmonary edema in the dog: with special reference to burns of the respiratory tract. Circ Res. 1959 Nov;7:1018–1030. doi: 10.1161/01.res.7.6.1018. [DOI] [PubMed] [Google Scholar]
  3. Aviado D. M. Pathologic physiology and chemotherapy of Plasmodium berghei. I. Suppression of parasitemia by sulfones and sulfonamides in mice. Exp Parasitol. 1967 Feb;20(1):88–97. doi: 10.1016/0014-4894(67)90026-4. [DOI] [PubMed] [Google Scholar]
  4. Aviado D. M., Sadavongvivad C. Pharmacological significance of biogenic amines in the lungs: noradrenaline and dopamine. Br J Pharmacol. 1970 Feb;38(2):374–385. doi: 10.1111/j.1476-5381.1970.tb08525.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Aviado D. M., Samanék M., Folle L. E. Cardiopulmonary effects of tobacco and related substances. I. The release of histamine during inhalation of cigarette smoke and anoxemia in the heart-lung and intact dog preparation. Arch Environ Health. 1966 Jun;12(6):705–711. doi: 10.1080/00039896.1966.10664468. [DOI] [PubMed] [Google Scholar]
  6. Carrillo L. R., Aviado D. M. Mechanisms for the bronchodilator effects of corticosteroids in the sensitized rabbit. J Pharmacol Exp Ther. 1968 Dec;164(2):302–311. [PubMed] [Google Scholar]
  7. ENGELHARDT G., SCHWABE U. [On 5-hydroxytryptamine liberation in anaphylactic reaction in the guinea pig]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1960;239:170–183. [PubMed] [Google Scholar]
  8. GRAHAM H. T., HANNEGAN T. W., NOURSE C. M. Dependence of tissue histamine content on local histidine decarboxylase activity. Biochim Biophys Acta. 1956 Apr;20(1):243–250. doi: 10.1016/0006-3002(56)90283-9. [DOI] [PubMed] [Google Scholar]
  9. GRAHAM H. T., LOWRY O. H., WHEELWRIGHT F., LENZ M. A., PARISH H. H., Jr Distribution of histamine among leukocytes and platelets. Blood. 1955 May;10(5):467–481. [PubMed] [Google Scholar]
  10. Hauge A., Melmon K. L. Role of histamine in hypoxic pulmonary hypertension in the rat. II. Depletion of histamine, serotonin, and catecholamines. Circ Res. 1968 Mar;22(3):385–392. doi: 10.1161/01.res.22.3.385. [DOI] [PubMed] [Google Scholar]
  11. MOTA I., VUGMAN I. Action of compound 48/80 on the mast cells and histamine content of guinea-pig tissues. Br J Pharmacol Chemother. 1956 Sep;11(3):304–307. doi: 10.1111/j.1476-5381.1956.tb01070.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. PARRATT J. R., WEST G. B. Release of 5-hydroxytryptamine and histamine from tissues of the rat. J Physiol. 1957 Jul 11;137(2):179–192. doi: 10.1113/jphysiol.1957.sp005805. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. RILEY J. F., WEST G. B. The presence of histamine in tissue mast cells. J Physiol. 1953 Jun 29;120(4):528–537. doi: 10.1113/jphysiol.1953.sp004915. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sadavongvivad C., Aviado D. M. Pathologic physiology and chemotherapy of Plasmodium berghei. VI. Mechanical properties and histological features of the lung. Exp Parasitol. 1969 Jun;24(3):313–326. doi: 10.1016/0014-4894(69)90170-2. [DOI] [PubMed] [Google Scholar]
  15. Sadavongvivad C. Pharmacological significance of biogenic amines in the lungs: 5-hydroxytryptamine. Br J Pharmacol. 1970 Feb;38(2):353–365. doi: 10.1111/j.1476-5381.1970.tb08523.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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