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. 1996 Mar;3(2):233–235. doi: 10.1128/cdli.3.2.233-235.1996

Release of soluble tumor necrosis factor receptors in Mediterranean spotted fever rickettsiosis.

W V Kern 1, J Oristrell 1, F Segura-Porta 1, P Kern 1
PMCID: PMC170287  PMID: 8991643

Abstract

Tumor necrosis factor alpha (TNF) is a key cytokine in the defense against many intracellular pathogens, including Rickettsia conorii, the causative agent of Mediterranean spotted fever (MSF). The levels of two soluble TNF receptors (sTNFR-p55 and sTNFR-p75), the extracellular domains of the two cell surface receptors for TNF, were elevated in the acute-stage plasma samples from 20 patients with serologically confirmed MSF. The median values were 3.1 and 7.8 ng/ml for sTNFR-p55 and sTNFR-p75, respectively. sTNFR values correlated significantly with plasma TNF concentrations. Patients with severe MSF had higher values for both receptor fragments than patients with nonsevere disease. The differences were statistically significant for sTNFR-p55 (median, 5.8 versus 2.0 ng/ml; P = 0.008). Given the proportionately higher values for both TNF and sTNFR-p55 in patients with severe MSF, the sTNFR-p55/TNF ratios for the two patient subgroups did not differ (P = 0.5), while the sTNFR-p75/TNF ratios were significantly different (P = 0.01), with disproportionately lower values in patients with severe disease.

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Selected References

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  1. Aukrust P., Liabakk N. B., Müller F., Lien E., Espevik T., Frøland S. S. Serum levels of tumor necrosis factor-alpha (TNF alpha) and soluble TNF receptors in human immunodeficiency virus type 1 infection--correlations to clinical, immunologic, and virologic parameters. J Infect Dis. 1994 Feb;169(2):420–424. doi: 10.1093/infdis/169.2.420. [DOI] [PubMed] [Google Scholar]
  2. Engelmann H., Holtmann H., Brakebusch C., Avni Y. S., Sarov I., Nophar Y., Hadas E., Leitner O., Wallach D. Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity. J Biol Chem. 1990 Aug 25;265(24):14497–14504. [PubMed] [Google Scholar]
  3. Feng H. M., Popov V. L., Walker D. H. Depletion of gamma interferon and tumor necrosis factor alpha in mice with Rickettsia conorii-infected endothelium: impairment of rickettsicidal nitric oxide production resulting in fatal, overwhelming rickettsial disease. Infect Immun. 1994 May;62(5):1952–1960. doi: 10.1128/iai.62.5.1952-1960.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Feng H. M., Wen J., Walker D. H. Rickettsia australis infection: a murine model of a highly invasive vasculopathic rickettsiosis. Am J Pathol. 1993 May;142(5):1471–1482. [PMC free article] [PubMed] [Google Scholar]
  5. Girardin E., Roux-Lombard P., Grau G. E., Suter P., Gallati H., Dayer J. M. Imbalance between tumour necrosis factor-alpha and soluble TNF receptor concentrations in severe meningococcaemia. The J5 Study Group. Immunology. 1992 May;76(1):20–23. [PMC free article] [PubMed] [Google Scholar]
  6. Kern P., Hemmer C. J., Gallati H., Neifer S., Kremsner P., Dietrich M., Porzsolt F. Soluble tumor necrosis factor receptors correlate with parasitemia and disease severity in human malaria. J Infect Dis. 1992 Oct;166(4):930–934. doi: 10.1093/infdis/166.4.930. [DOI] [PubMed] [Google Scholar]
  7. Kern P., Kern W. V., Kremsner P. Soluble tumor necrosis factor receptors in Plasmodium vivax malaria. J Infect Dis. 1993 Nov;168(5):1340–1341. doi: 10.1093/infdis/168.5.1340. [DOI] [PubMed] [Google Scholar]
  8. Kern W. V., Engel A., Schieffer S., Prümmer O., Kern P. Circulating tumor necrosis factor alpha (TNF), soluble TNF receptors, and interleukin-6 in human subacute bacterial endocarditis. Infect Immun. 1993 Dec;61(12):5413–5416. doi: 10.1128/iai.61.12.5413-5416.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Keuter M., Dharmana E., Gasem M. H., van der Ven-Jongekrijg J., Djokomoeljanto R., Dolmans W. M., Demacker P., Sauerwein R., Gallati H., van der Meer J. W. Patterns of proinflammatory cytokines and inhibitors during typhoid fever. J Infect Dis. 1994 Jun;169(6):1306–1311. doi: 10.1093/infdis/169.6.1306. [DOI] [PubMed] [Google Scholar]
  10. Mackay F., Loetscher H., Stueber D., Gehr G., Lesslauer W. Tumor necrosis factor alpha (TNF-alpha)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55. J Exp Med. 1993 May 1;177(5):1277–1286. doi: 10.1084/jem.177.5.1277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Manor E., Sarov I. Inhibition of Rickettsia conorii growth by recombinant tumor necrosis factor alpha: enhancement of inhibition by gamma interferon. Infect Immun. 1990 Jun;58(6):1886–1890. doi: 10.1128/iai.58.6.1886-1890.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Manor E., Sarov I. Tumor necrosis factor alpha and prostaglandin E2 production by human monocyte-derived macrophages infected with spotted fever group rickettsiae. Ann N Y Acad Sci. 1990;590:157–167. doi: 10.1111/j.1749-6632.1990.tb42218.x. [DOI] [PubMed] [Google Scholar]
  13. Oristrell J., Amengual M. J., Font-Creus B., Casanovas A., Segura-Porta F. Plasma levels of tumor necrosis factor alpha in patients with Mediterranean spotted fever: clinical and analytical correlations. Clin Infect Dis. 1994 Dec;19(6):1141–1143. doi: 10.1093/clinids/19.6.1141. [DOI] [PubMed] [Google Scholar]
  14. Pfeffer K., Matsuyama T., Kündig T. M., Wakeham A., Kishihara K., Shahinian A., Wiegmann K., Ohashi P. S., Krönke M., Mak T. W. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell. 1993 May 7;73(3):457–467. doi: 10.1016/0092-8674(93)90134-c. [DOI] [PubMed] [Google Scholar]
  15. Spinas G. A., Keller U., Brockhaus M. Release of soluble receptors for tumor necrosis factor (TNF) in relation to circulating TNF during experimental endotoxinemia. J Clin Invest. 1992 Aug;90(2):533–536. doi: 10.1172/JCI115891. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Tartaglia L. A., Goeddel D. V. Two TNF receptors. Immunol Today. 1992 May;13(5):151–153. doi: 10.1016/0167-5699(92)90116-O. [DOI] [PubMed] [Google Scholar]
  17. Tartaglia L. A., Pennica D., Goeddel D. V. Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor. J Biol Chem. 1993 Sep 5;268(25):18542–18548. [PubMed] [Google Scholar]
  18. Tartaglia L. A., Rothe M., Hu Y. F., Goeddel D. V. Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor. Cell. 1993 Apr 23;73(2):213–216. doi: 10.1016/0092-8674(93)90222-c. [DOI] [PubMed] [Google Scholar]
  19. Van Zee K. J., Kohno T., Fischer E., Rock C. S., Moldawer L. L., Lowry S. F. Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo. Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):4845–4849. doi: 10.1073/pnas.89.11.4845. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. van Deuren M., van der Ven-Jongekrijg J., Demacker P. N., Bartelink A. K., van Dalen R., Sauerwein R. W., Gallati H., Vannice J. L., van der Meer J. W. Differential expression of proinflammatory cytokines and their inhibitors during the course of meningococcal infections. J Infect Dis. 1994 Jan;169(1):157–161. doi: 10.1093/infdis/169.1.157. [DOI] [PubMed] [Google Scholar]
  21. van der Poll T., Jansen J., van Leenen D., von der Möhlen M., Levi M., ten Cate H., Gallati H., ten Cate J. W., van Deventer S. J. Release of soluble receptors for tumor necrosis factor in clinical sepsis and experimental endotoxemia. J Infect Dis. 1993 Oct;168(4):955–960. doi: 10.1093/infdis/168.4.955. [DOI] [PubMed] [Google Scholar]

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