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. 1970 May;39(1):139–148. doi: 10.1111/j.1476-5381.1970.tb09563.x

1-Isopropylamino-3-(4-indanoxy)-2-propanol HCl

A potent β-adrenoceptor antagonist

B Levy, M Wasserman
PMCID: PMC1702934  PMID: 4392959

Abstract

1. The β-adrenoceptor blocking activity of 1-isopropylamino-3-(4-indanoxy)-2-propanol HCl (USVC 6524) was determined in the anaesthetized dog, the isolated rat uterus and the isolated guinea-pig tracheal strip.

2. USVC 6524 inhibited the positive inotropic, positive chronotropic and vasodilator responses to isoprenaline in the dog in a dose of 10 μg/kg and higher. On the basis of comparative pA2 values, USVC 6524 is approximately 10 times more potent as a β-adrenoceptor antagonist than propranolol.

3. Cardiac depressant effects produced by USVC 6524 were relatively mild and occurred only after the onset of a strong β-adrenoceptor blockade.

4. USVC 6524 also blocked β-adrenoceptors in the isolated rat uterus and guinea-pig tracheal spiral strip.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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