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. 1970 May;39(1):34–39. doi: 10.1111/j.1476-5381.1970.tb09553.x

The action of angiotensin on the human colon in vitro

D J Fishlock, A Gunn
PMCID: PMC1702935  PMID: 4315990

Abstract

1. The action of angiotensin on the circular and longitudinal muscle of the human colon has been studied in vitro. The ED50 value (g/ml) of circular muscle was 8·7 × 10-8 and of longitudinal muscle 3·1 × 10-8, while the corresponding figures for acetylcholine were 1·6 × 10-6 and 1·1 × 10-6, respectively. Angiotensin caused a sustained contraction associated with prolonged tachyphylaxis.

2. As the action of angiotensin was not antagonized by atropine, hexa-methonium or procaine, angiotensin appeared to act directly on the smooth muscle of the human colon.

3. Lidoflazine is not a specific antagonist of angiotensin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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