Skip to main content
British Journal of Pharmacology logoLink to British Journal of Pharmacology
letter
. 1970 Nov;40(3):528–530. doi: 10.1111/j.1476-5381.1970.tb10637.x

Inhibition of catecholamine Uptake2 by steroids in the isolated rat heart

L L Iversen, P J Salt
PMCID: PMC1703119  PMID: 5497802

Abstract

Various steroids (17-β-oestradiol, corticosterone, deoxycorticosterone, progesterone, testosterone and androsterone) produced a dose-dependent inhibition of the uptake of 3H-noradrenaline by the Uptake2 mechanism in the isolated perfused heart. It is suggested that these results may explain the potentiating effects of such steroids on the responses of vascular smooth muscle to catecholamines.

Full text

PDF
528

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Kalsner S. Mechanism of hydrocortisone potentiation of responses to epinephrine and norepinephrine in rabbit aorta. Circ Res. 1969 Mar;24(3):383–395. doi: 10.1161/01.res.24.3.383. [DOI] [PubMed] [Google Scholar]
  2. Kalsner S. Steroid potentiation of responses to sympathomimetic amines in aortic strips. Br J Pharmacol. 1969 Jul;36(3):582–593. doi: 10.1111/j.1476-5381.1969.tb08013.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Lightman S. L., Iversen L. L. The role of uptake2 in the extraneuronal metabolism of catecholamines in the isolated rat heart. Br J Pharmacol. 1969 Nov;37(3):638–649. doi: 10.1111/j.1476-5381.1969.tb08502.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. SCHAYER R. W. A UNIFIED THEORY OF GLUCOCORTICOID ACTION. Perspect Biol Med. 1964;7:71–84. doi: 10.1353/pbm.1964.0006. [DOI] [PubMed] [Google Scholar]
  5. ZWEIFACH B. W., SHORR E., BLACK M. M. The influence of the adrenal cortex on behavior of terminal vascular bed. Ann N Y Acad Sci. 1953 Jul 17;56(4):626–633. doi: 10.1111/j.1749-6632.1953.tb27383.x. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES