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. 1970 Nov;40(3):483–491. doi: 10.1111/j.1476-5381.1970.tb10629.x

Turnover rate of brain 5-hydroxytryptamine increased by D-amphetamine

W D Reid
PMCID: PMC1703177  PMID: 4395745

Abstract

1. Administration of two doses of amphetamine HCl (5 mg/kg intraperitoneally) 45 min apart raised body temperature of rats by an average of 3·4° C and increased the turnover rate of brain 5-hydroxytryptamine (5-HT) by almost one-half.

2. Both effects were blocked by exposure to 4° C or by pretreatment with the β-blocker Kö 592 (1-(2-methylphenoxy)-3-isopropylamine-2-propanol), but not by the administration of the ganglionic blocker chlorisondamine combined with atropine.

3. Since it has previously been shown that hyperthermia per se increases the turnover rate of brain 5-HT, and that amphetamine does not directly affect the uptake and release of 5-HT in brain slices, it is concluded that the amphetamine-induced increase in 5-HT turnover may be secondary to the rise in temperature produced by the drug.

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Selected References

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