Abstract
1. The effects of some amino-acid esters possessing both muscarinic and nicotinic activity have been investigated on the cat superior cervical ganglion. The compounds were applied to the ganglion in vivo by close intra-arterial injection and responses were measured by contraction of the nictitating membrane or by recording post ganglionic compound action potentials.
2. The esters, like carbachol, produced effects which were blocked by hexamethonium and reduced by atropine. Pretreatment with an anticholinesterase agent had no effect on the response and the chronically denervated ganglion was, if anything, slightly more sensitive to the drugs.
3. Effects of standard muscarinic and nicotinic drugs were also studied and the results support the view that both muscarinic and nicotinic receptors are present in the ganglion.
4. From the results of this investigation it appears that the amino-acid esters and carbachol produce their effects by interacting with post synaptic receptors in the ganglion. This is in contrast to other results in the literature which suggest that the receptors might be presynaptic. Further studies are required to resolve this difference.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- AMBACHE N., PERRY W. L., ROBERTSON P. A. The effect of muscarine on perfused superior cervical ganglia of cats. Br J Pharmacol Chemother. 1956 Dec;11(4):442–448. doi: 10.1111/j.1476-5381.1956.tb00014.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barrass B. C., Brimblecombe R. W., Parkes D. C., Rich P. The cholinergic properties of some amino-acid esters and amides. Br J Pharmacol. 1968 Oct;34(2):345–357. doi: 10.1111/j.1476-5381.1968.tb07056.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown D. A. Effects of preganglionic denervation on the sensitivity of sympathetic ganglion cells to stimulant compounds. J Physiol. 1968 May;196(2):117P–118P. [PubMed] [Google Scholar]
- JONES A. GANGLIONIC ACTIONS OF MUSCARINIC SUBSTANCES. J Pharmacol Exp Ther. 1963 Aug;141:195–205. [PubMed] [Google Scholar]
- KOELLE W. A., KOELLE G. B. The localization of external or functional acetylcholinesterase at the synapses of autonomic ganglia. J Pharmacol Exp Ther. 1959 May;126(1):1–8. [PubMed] [Google Scholar]
- KONZETT H., WASER P. G. Zur ganglionären Wirkung von Muscarin. Helv Physiol Pharmacol Acta. 1956;14(2):202–206. [PubMed] [Google Scholar]
- LEVY B., AHLQUIST R. P. A study of sympathetic ganglionic stimulants. J Pharmacol Exp Ther. 1962 Aug;137:219–228. [PubMed] [Google Scholar]
- TAKESHIGE C., VOLLE R. L. Asynchronous postganglionic firing from the cat superior cervical sympathetic ganglion treated with neostigmine. Br J Pharmacol Chemother. 1963 Feb;20:214–220. doi: 10.1111/j.1476-5381.1963.tb01311.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TAKESHIGE C., VOLLE R. L. Bimodal response of sympathetic ganglia to acetylcholine following eserine or repetitive preganglionic stimulation. J Pharmacol Exp Ther. 1962 Oct;138:66–73. [PubMed] [Google Scholar]
- VOLLE R. L., KOELLE G. B. The physiological role of acetyl-cholinesterase (AChE) in sympathetic ganglia. J Pharmacol Exp Ther. 1961 Aug;133:223–240. [PubMed] [Google Scholar]