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. 1968 Sep;34(1):141–147. doi: 10.1111/j.1476-5381.1968.tb07957.x

The effects of some β-adrenoreceptor blocking drugs on the uptake and release of noradrenaline by the heart

J W Foo, Alison Jowett, Anne Stafford
PMCID: PMC1703465  PMID: 4386370

Abstract

1. The potencies of some β-adrenoreceptor blocking drugs in reducing noradrenaline uptake by the isolated heart were compared with their potencies in reducing the release of noradrenaline from the heart by tyramine.

2. Of the drugs tested, propranolol, pronethalol and dichloroisoprenaline were the most potent in blocking uptake and release of noradrenaline, although none was at potent as cocaine; MJ 1999 and I.C.I. 50172 were only weakly effective.

3. Pronethalol and dichloroisoprenaline each reduced release of noradrenaline by tyramine in the concentration range (10-7-10-6M) where blockade of responses to tyramine was apparent; with these drugs both reduction of noradrenaline release and β-receptor blockade contribute to the reduction in responses to tyramine.

4. Potency of β-receptor blocking drugs in reducing noradrenaline uptake is unrelated to potency in blocking β-receptors; Kö 592 blocks β-receptors without affecting noradrenaline uptake.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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