Skip to main content
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1968 Nov;34(3):475–483. doi: 10.1111/j.1476-5381.1968.tb08475.x

Action of various sympathomimetic amines on the isolated stripped vas deferens of the guinea-pig

O A Nedergaard, E Westermann
PMCID: PMC1703513  PMID: 4302376

Abstract

1. The contractile potencies of some sympathomimetic amines and cholinergic drugs were studied in the isolated, stripped vas deferens of the guinea-pig.

2. α-Methylnoradrenaline, adrenaline and metaraminol produced the same relative maximal responses as noradrenaline, which served as reference drug; on the other hand, octopamine, dopamine and α-methyldopamine were much less active. Short term pretreatment of the animals with reserpine did not affect the maximal relative responses.

3. Tyramine, α-methyl-m-tyramine and hordenine methiodide had little effect on the untreated preparation. In the presence of just threshold concentrations of noradrenaline, the relative maximal responses to tyramine and hordenine methiodide were markedly increased.

4. The relative maximal response to carbachol was the same as that to noradrenaline, while that to DMPP was smaller. In contrast to carbachol, the action of DMPP was potentiated by pretreatment of the preparation with noradrenaline.

Full text

PDF
475

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENTLEY G. A., SABINE J. R. THE EFFECTS OF GANGLION-BLOCKING AND POSTGANGLIONIC SYMPATHOLYTIC DRUGS ON PREPARATIONS OF THE GUINEA-PIG VAS DEFERENS. Br J Pharmacol Chemother. 1963 Aug;21:190–201. doi: 10.1111/j.1476-5381.1963.tb01515.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BURN J. H., RAND M. J. The action of sympathomimetic amines in animals treated with reserpine. J Physiol. 1958 Dec 4;144(2):314–336. doi: 10.1113/jphysiol.1958.sp006104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BURN J. H., RAND M. J. The cause of the supersensitivity of smooth muscle to noradrenaline after sympathetic degeneration. J Physiol. 1959 Jun 23;147(1):135–143. doi: 10.1113/jphysiol.1959.sp006228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DELLABELLA D., BENELLI G., GANDINI A. ESERINE AND AUTONOMIC NERVOUS CONTROL OF GUINEA-PIG VAS DEFERENS. J Pharm Pharmacol. 1964 Dec;16:779–787. doi: 10.1111/j.2042-7158.1964.tb07410.x. [DOI] [PubMed] [Google Scholar]
  5. FALCK B., OWMAN C., SJOSTRAND N. O. PERIPHERALLY LOCATED ADRENERGIC NEURONS INNERVATING THE VAS DEFERENS AND THE SEMINAL VESICLE OF THE GUINEA-PIG. Experientia. 1965 Feb 15;21:98–100. doi: 10.1007/BF02144766. [DOI] [PubMed] [Google Scholar]
  6. FURCHGOTT R. F., BHADRAKOM S. Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs. J Pharmacol Exp Ther. 1953 Jun;108(2):129–143. [PubMed] [Google Scholar]
  7. Holtz P., Palm D. Brenzkatechinamine und andere sympathicomimetische Amine. Biosynthese und Inaktivierung. Freisetzung und Wirkung. Ergeb Physiol. 1966;58:1–580. [PubMed] [Google Scholar]
  8. Kopin I. J. Biochemical aspects of release of norepinephrine and other amines from sympathetic nerve endings. Pharmacol Rev. 1966 Mar;18(1):513–523. [PubMed] [Google Scholar]
  9. Lindmar R., Muscholl E. Die Verstärkung der Noradrenalinwirkung durch Tyramin. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 Nov 18;252(2):122–133. [PubMed] [Google Scholar]
  10. OHLIN P., STROMBLAD B. C. Observations on the isolated vas deferens. Br J Pharmacol Chemother. 1963 Apr;20:299–306. doi: 10.1111/j.1476-5381.1963.tb01469.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. SJOSTRAND N. O. Effect of reserpine and hypogastric denervation on the noradrenaline content of the vas deferens and the seminal vesicle of the guinea-pig. Acta Physiol Scand. 1962 Nov-Dec;56:376–380. doi: 10.1111/j.1748-1716.1962.tb02513.x. [DOI] [PubMed] [Google Scholar]
  12. TRENDELENBURG U., CROUT J. R. THE NOREPINEPHRINE STORES OF ISOLATED ATRIA OF GUINEA PIGS PRETREATED WITH RESERPINE. J Pharmacol Exp Ther. 1964 Aug;145:151–161. [PubMed] [Google Scholar]
  13. Trendelenburg U. Mechanisms of supersensitivity and subsensitivity to sympathomimetic amines. Pharmacol Rev. 1966 Mar;18(1):629–640. [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES