Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1969 Jul;36(3):549–560. doi: 10.1111/j.1476-5381.1969.tb08010.x

Blockade or reversal of the contraction induced by calcium and adrenaline in depolarized arterial smooth muscle

T Godfraind, A Kaba
PMCID: PMC1703600  PMID: 4389283

Abstract

1. Mesenteric arteries immersed in a depolarizing solution contract in the presence of calcium. These contractions are proportional to the calcium concentration and are reversible.

2. Mesenteric arteries immersed in a calcium-free depolarizing solution contract in the presence of adrenaline. Under the experimental conditions reported here, this response develops only about one-third of the contractile tension developed in polarizing solution (modified Krebs bicarbonate).

3. Cinnarizine and chlorpromazine inhibit the contractile response to calcium and induce relaxation of depolarized muscle previously contracted by calcium; cinnarizine was 4 times more potent than chlorpromazine in such activity.

4. Chlorpromazine inhibits the response to adrenaline in both polarizing and calcium-free depolarizing solutions, whereas cinnarizine inhibits the response in polarizing solution but not that in calcium-free depolarizing solution.

5. The significance of these results is discussed.

Full text

PDF
549

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARIUENS E. J., SIMONIS A. M. A MOLECULAR BASIS FOR DRUG ACTION. J Pharm Pharmacol. 1964 Mar;16:137–157. doi: 10.1111/j.2042-7158.1964.tb07437.x. [DOI] [PubMed] [Google Scholar]
  2. BEVAN J. A., OSHER J. V., SU C. Response of vascular smooth muscle to potassium and its antagonism by phenoxybenzamine. J Pharmacol Exp Ther. 1963 Feb;139:216–221. [PubMed] [Google Scholar]
  3. Balzer H., Makinose M. The inhibition of the sarcoplasmic calcium pump produced by agents which react with its lipid component: reserpine, prenylamine, chlorpromazine, imipramine. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1968;259(2):151–152. doi: 10.1007/BF00537745. [DOI] [PubMed] [Google Scholar]
  4. Bohr D. F. Adrenergic receptors in coronary arteries. Ann N Y Acad Sci. 1967 Feb 10;139(3):799–807. doi: 10.1111/j.1749-6632.1967.tb41248.x. [DOI] [PubMed] [Google Scholar]
  5. DURBIN R. P., JENKINSON D. H. The calcium dependence of tension development in depolarized smooth muscle. J Physiol. 1961 Jun;157:90–96. doi: 10.1113/jphysiol.1961.sp006707. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. EDMAN K. A., SCHILD H. O. The need for calcium in the contractile responses induced by acetylcholine and potassium in the rat uterus. J Physiol. 1962 May;161:424–441. doi: 10.1113/jphysiol.1962.sp006897. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Feinstein M. B., Paimre M., Lee M. Effect of local anesthetics on excitation-coupling mechanisms. Trans N Y Acad Sci. 1968 Jun;30(8):1073–1081. doi: 10.1111/j.2164-0947.1968.tb02556.x. [DOI] [PubMed] [Google Scholar]
  8. Godfraind T., Kaba A., Polster P. Differences in sensitivity of arterial smooth muscles to inhibition of their contractile response to depolarization by potassium. Arch Int Pharmacodyn Ther. 1968 Mar;172(1):235–239. [PubMed] [Google Scholar]
  9. Godfraind T., Polster P. Etude comparative de médicaments inhibant la réponse contractile de vaisseaux isolésd'origine humaine ou animale. Therapie. 1968 Sep-Oct;23(5):1209–1220. [PubMed] [Google Scholar]
  10. Hudgins P. M., Weiss G. B. Differential effects of calcium removal upon vascular smooth muscle contraction induced by norepinephrine, histamine and potassium. J Pharmacol Exp Ther. 1968 Jan;159(1):91–97. [PubMed] [Google Scholar]
  11. Scales B., McIntosh D. A. Studies on the radiocalcium uptake and the adenosine triphosphatases of skeletal and cardiac sarcoplasmic reticulum fractions (SRF). J Pharmacol Exp Ther. 1968 Apr;160(2):249–260. [PubMed] [Google Scholar]
  12. Schild H. O. Calcium and the relaxant effect of isoproterenol in the depolarized rat uterus. Pharmacol Rev. 1966 Mar;18(1):495–501. [PubMed] [Google Scholar]
  13. Schild H. O. The action of isoprenaline in the depolarized rat uterus. Br J Pharmacol Chemother. 1967 Nov;31(3):578–592. doi: 10.1111/j.1476-5381.1967.tb00422.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Shibata S., Carrier O., Jr Antagonizing action of chlorpromazine, dibenamine, and phenoxybenzamine on potassium-induced contraction. Can J Physiol Pharmacol. 1967 Jul;45(4):587–596. doi: 10.1139/y67-071. [DOI] [PubMed] [Google Scholar]
  15. Somlyo A. V., Somlyo A. P. Electromechanical and pharmacomechanical coupling in vascular smooth muscle. J Pharmacol Exp Ther. 1968 Jan;159(1):129–145. [PubMed] [Google Scholar]
  16. Sullivan L. J., Briggs A. H. Effects of manganese on the response of aortic strips to angiotensin and norepinephrine contractions. J Pharmacol Exp Ther. 1968 Jun;161(2):205–209. [PubMed] [Google Scholar]
  17. VAN NUETENJ, DRESSE A., DONY J. ACTION ANTAGONISTE DE LA CINNARIZINE VIS-'A-VIS DE L'ANGIOTENSINE IN VITRO. C R Seances Soc Biol Fil. 1964;158:1750–1754. [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES