Abstract
1. The action of adrenaline on the K+ balance of the isolated heart was found to depend on the ionic composition and the temperature of the perfusion fluids used.
2. When the perfusion fluid contained 145 mM Na+, 1·7 mM Ca++ and 3-9 mM K+, adrenaline caused the hearts to gain K+; when the K+ concentration was reduced to 1·2 mM, adrenaline caused a loss of K+. Both were actions on β receptors.
3. When the Ca++ or the Na+ concentration in the perfusion fluid was reduced, together with a reduction in K+, adrenaline no longer produced K+ loss from the hearts, but produced a gain of K+.
4. When the temperature of the perfusion fluid was reduced to 25° C, adrenaline still produced a gain of K+ by hearts perfused with fluid containing 3·2 mM K+, but did not produce a loss of K+ from hearts perfused with fluid containing 1·2 mM K+.
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Selected References
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