Abstract
Experiments on the isolated vas deferens of guinea-pig and rat had unexpected results in several ways. The effect of stimulation of the hypogastric nerve was not abolished, but increased, by parasympathetic blocking agents or by sympathetic blocking agents such as dihydroergotamine and phenoxybenzamine. The sensitization is considered not due to anticholinesterase activity of the drugs. Prolonged contact with a stimulating agent evoked rhythmic contractions. Addition as well as removal of a drug from the bath caused a response. The results of experiments involving chronic denervation, addition of hexamethonium and histological examination tally with the assumption of a distribution of ganglionic cells along the nerve just outside the organ.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BERTLER A., CARLSSON A., ROSENGREN E. A method for the fluorimetric determination of adrenaline and noradrenaline in tissues. Acta Physiol Scand. 1958 Dec 15;44(3-4):273–292. doi: 10.1111/j.1748-1716.1958.tb01627.x. [DOI] [PubMed] [Google Scholar]
- BULBRING E. Changes in configuration of spontaneously discharged spike potentials from smooth muscle of the guinea-pig's taenia coli; the effect of electrotonic currents and of adrenaline, acetylcholine and histamine. J Physiol. 1957 Feb 15;135(2):412–425. doi: 10.1113/jphysiol.1957.sp005720. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BURNSTOCK G., HOLMAN M. E. Effect of denervation and of reserpine treatment on transmission at sympathetic nerve endings. J Physiol. 1962 Mar;160:461–469. doi: 10.1113/jphysiol.1962.sp006859. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BURNSTOCK G., HOLMAN M. E. Spontaneous potential at sympathetic nerve endings in smooth muscle. J Physiol. 1962 Mar;160:446–460. doi: 10.1113/jphysiol.1962.sp006858. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BURNSTOCK G., HOLMAN M. E. The transmission of excitation from autonomic nerve to smooth muscle. J Physiol. 1961 Jan;155:115–133. doi: 10.1113/jphysiol.1961.sp006617. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HEBB C. O., WAITES G. M. Choline acetylase in antero- and retro-grade degeneration of a cholinergic nerve. J Physiol. 1956 Jun 28;132(3):667–671. doi: 10.1113/jphysiol.1956.sp005556. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NORDENFELT I. Choline acetylase in normal and denervated salivary glands. Q J Exp Physiol Cogn Med Sci. 1963 Jan;48:67–79. doi: 10.1113/expphysiol.1963.sp001639. [DOI] [PubMed] [Google Scholar]
- RAND M. J., CHANG V. New evidence for a cholinergic process in sympathetic transmission. Nature. 1960 Dec 3;188:858–859. doi: 10.1038/188858a0. [DOI] [PubMed] [Google Scholar]