The effect of aflatoxin on blood clotting in the rat

PMCID: PMC1703652 PMID: 5348434

Abstract

1. The action of aflatoxin on blood clotting of rats was investigated. Aflatoxin B₁ prolonged the blood clotting time of rats.

2. Aflatoxin B₁ was effective as an anticoagulant in much smaller doses than 4-hydroxycoumarin.

These references are in PubMed. This may not be the complete list of references from this article.

Coomes T. J., Crowther P. C., Francis B. J., Stevens L. The detection and estimation of aflatoxin in groundnuts and groundnut materials. IV. Routine assessment of toxicity due to aflatoxin B1. Analyst. 1965 Aug;90(73):492–496. doi: 10.1039/an9659000492. [DOI] [PubMed] [Google Scholar]
Newberne P. M., Russo R., Wogan G. N. Acute toxicity of aflatoxin B1 in the dog. Pathol Vet. 1966;3(4):331–340. doi: 10.1177/030098586600300403. [DOI] [PubMed] [Google Scholar]
OWREN P. A. Thrombotest. A new method for controlling anticoagulant therapy. Lancet. 1959 Nov 7;2(7106):754–758. doi: 10.1016/s0140-6736(59)90857-8. [DOI] [PubMed] [Google Scholar]
Schoental R. Aflatoxins. Annu Rev Pharmacol. 1967;7:343–356. doi: 10.1146/annurev.pa.07.040167.002015. [DOI] [PubMed] [Google Scholar]