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. 1963 Feb;20(1):63–73. doi: 10.1111/j.1476-5381.1963.tb01297.x

Facilitation of neuromuscular transmission by anticholinesterase drugs

L C Blaber
PMCID: PMC1703737  PMID: 13971349

Abstract

A close correlation has been shown to exist between the in vitro anticholinesterase potencies of ambenonium, neostigmine, methoxyambenonium and edrophonium chloride and their abilities to increase muscle contractions produced by close-arterial injections of acetylcholine. No correlation was found between the anticholinesterase potencies of the drugs and their potentiations of the maximal twitch in response to electrical stimulation, or their antagonisms of tubocurarine. It is concluded that some action, in addition to inhibition of cholinesterase, contributed to their facilitation at the neuromuscular junction, and it is suggested that this action may be at the prejunctional site.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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