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. 1963 Feb;20(1):5–16. doi: 10.1111/j.1476-5381.1963.tb01292.x

Stimulus frequency and neuromuscular block

J G Blackman
PMCID: PMC1703751  PMID: 13971398

Abstract

Muscle twitches of the rat isolated diaphragm and frog sartorius preparations were recorded. It was confirmed that, in the presence of tubocurarine, the degree of neuromuscular block was greater the higher the frequency of stimulation. The results suggest that the quantity of acetylcholine released by each nerve impulse was reduced by increasing the rate of stimulation so that, in a tubocurarine solution, muscle fibres which were only just being fired at a slow rate of stimulation failed to fire at a faster rate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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