Abstract
Estimations have been made of the amounts of adrenaline, noradrenaline and 5-hydroxytryptamine released by iontophoresis from micropipettes. In most experiments, the amount released was linearly related to the total electrical charge, but the transport numbers for different pipettes, filled with samples of the same solutions of adrenaline or of noradrenaline, varied substantially. Two pipettes containing noradrenaline failed to release any appreciable amounts of the drug. The transport number of 5-hydroxytryptamine was relatively constant (mean, 0.14).
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- BRADLEY P. B., WOLSTENCROFT J. H. Excitaion and inhibition of brain-stem neurones by noradrenaline and acetylcholine. Nature. 1962 Dec 1;196:840–passim. doi: 10.1038/196840a0. [DOI] [PubMed] [Google Scholar]
- CURTIS D. R., DAVIS R. Pharmacological studies upon neurones of the lateral geniculate nucleus of the cat. Br J Pharmacol Chemother. 1962 Apr;18:217–246. doi: 10.1111/j.1476-5381.1962.tb01404.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KRNJEVIC K., MITCHELL J. F., SZERB J. C. Determination of iontophoretic release of acetylcholine from micropipettes. J Physiol. 1963 Mar;165:421–436. doi: 10.1113/jphysiol.1963.sp007067. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KRNJEVIC K., PHILLIS J. W. Actions of certain amines on cerebral cortical neurones. Br J Pharmacol Chemother. 1963 Jun;20:471–490. doi: 10.1111/j.1476-5381.1963.tb01484.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KRNJEVIC K., PHILLIS J. W. Iontophoretic studies of neurones in the mammalian cerebral cortex. J Physiol. 1963 Feb;165:274–304. doi: 10.1113/jphysiol.1963.sp007057. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SHARMAN D. F., VANOV S., VOGT M. Noradrenaline content in the heart and spleen of the mouse under normal conditions and after administration of some drugs. Br J Pharmacol Chemother. 1962 Dec;19:527–533. doi: 10.1111/j.1476-5381.1962.tb01458.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- UDENFRIEND S., BOGDANSKI D. F., WEISSBACH H. Fluorescence characteristics of 5-hydroxytryptamine (serotonin). Science. 1955 Nov 18;122(3177):972–973. doi: 10.1126/science.122.3177.972. [DOI] [PubMed] [Google Scholar]