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British Journal of Pharmacology and Chemotherapy logoLink to British Journal of Pharmacology and Chemotherapy
. 1963 Oct;21(2):244–249. doi: 10.1111/j.1476-5381.1963.tb01523.x

The effects of choline and other factors on the release of acetylcholine from the stimulated perfused superior cervical ganglion of the cat

E K Matthews
PMCID: PMC1703831  PMID: 14081655

Abstract

When the superior cervical ganglion of the cat was perfused with Locke solution, the amount of acetylcholine released into the perfusate decreased during successive periods of repetitive stimulation of the preganglionic nerve. Addition of choline to the perfusion fluid prevented this decrease. Choline also significantly increased (P<0.01) the initial output of acetylcholine. In contrast, variation of the physostigmine concentration or of the pCO2 and pH of the perfusion fluid had no statistically significant effect (P>0.05) upon the initial release of acetylcholine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLIGH J. The level of free choline in plasma. J Physiol. 1952 Jun;117(2):234–240. doi: 10.1113/jphysiol.1952.sp004743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. EMMELIN N., MACINTOSH F. C. The release of acetylcholine from perfused sympathetic ganglia and skeletal muscles. J Physiol. 1956 Feb 28;131(2):477–496. doi: 10.1113/jphysiol.1956.sp005477. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Feldberg W., Gaddum J. H. The chemical transmitter at synapses in a sympathetic ganglion. J Physiol. 1934 Jun 9;81(3):305–319. doi: 10.1113/jphysiol.1934.sp003137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Feldberg W., Vartiainen A. Further observations on the physiology and pharmacology of a sympathetic ganglion. J Physiol. 1934 Dec 14;83(1):103–128. doi: 10.1113/jphysiol.1934.sp003214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. PERRY W. L. M. Acetylcholine release in the cat's superior cervical ganglion. J Physiol. 1953 Mar;119(4):439–454. doi: 10.1113/jphysiol.1953.sp004858. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. STRAUGHAN D. W. Assay of acetylcholine on the rat blood pressure. J Pharm Pharmacol. 1958 Dec;10(12):783–784. doi: 10.1111/j.2042-7158.1958.tb10376.x. [DOI] [PubMed] [Google Scholar]

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