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. 1963 Oct;21(2):220–225. doi: 10.1111/j.1476-5381.1963.tb01519.x

Plasma volume expansion by rapid infusion of a low molecular weight dextran

J W L Davies, C R Ricketts, B N Williams
PMCID: PMC1703837  PMID: 14081651

Abstract

Large infusions of a 10% solution of dextran of molecular weight 40,000 were given to dogs during 3 min using a specially designed apparatus. The initial expansion of plasma volume was about twice the volume of solution injected. Plasma volume then fell rapidly (with a half life of about 2 hr), more rapidly than the fall in dextran concentration (half-life of about 4.5 hr). Fluctuations in plasma volume and protein concentration were repeatedly observed during the return towards normal values. At 5 to 6 hr renal excretion accounted for 40% of the infused dextran, about 20% was intravascular and the remaining 40% was presumably extravascular. No dextran was found in the cerebrospinal fluid.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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