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. 1963 Aug;21(1):165–173. doi: 10.1111/j.1476-5381.1963.tb01512.x

Effects of bretylium and guanethidine on human hand and forearm vessels and on their sensitivity to noradrenaline

C J Cooper, J D Fewings, R L Hodge, R F Whelan
PMCID: PMC1703847  PMID: 14066141

Abstract

Infusions of bretylium and guanethidine into the brachial artery of normal subjects caused a fall in forearm and hand blood flow followed by a sustained increase in flow. The constrictor phase was attributed to catechol amine release since it was blocked by phenoxybenzamine. A slight and transient increase in response of the hand vessels to noradrenaline was seen after bretylium in the early constrictor phase before sympathetic block was complete. Guanethidine produced a more definite and sustained increase in the response of the hand vessels to noradrenaline. It is concluded that the phenomenon of tolerance which is conspicuous with bretylium and negligible with guanethidine is unlikely to be due to the rapid onset of hypersensitivity of the peripheral vessels.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABBOUD F. M., ECKSTEIN J. W., WENDLING M. G. Early potentiation of the vasoconstrictor action of norepinephrine by guanethidine. Proc Soc Exp Biol Med. 1962 Jul;110:489–492. doi: 10.3181/00379727-110-27559. [DOI] [PubMed] [Google Scholar]
  2. BARCROFT H., GASKELL P., SHEPHERD J. T., WHELAN R. F. The effect of noradrenaline infusions on the blood flow through the human forearm. J Physiol. 1954 Mar 29;123(3):443–450. doi: 10.1113/jphysiol.1954.sp005063. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BLAIR D. A., GLOVER W. E., GREENFIELD A. D., RODDIE I. C. Excitation of cholinergic vasodilator nerves to human skeletal muscles during emotional stress. J Physiol. 1959 Oct;148:633–647. doi: 10.1113/jphysiol.1959.sp006312. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BOURA A. L., GREEN A. F., McCOUBREY A., LAURENCE D. R., MOULTON R., ROSENHEIM M. L. Darenthin: hypotensive agent of new type. Lancet. 1959 Jul 11;2(7089):17–21. [PubMed] [Google Scholar]
  5. DUFF R. S. Effect of sympathectomy on the response to adrenaline of the blood vessels of the skin in man. J Physiol. 1952 Aug;117(4):415–430. doi: 10.1113/jphysiol.1952.sp004758. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FRENCH E. B., MATTHEWS M. B. Effects of brachial arterial infusion of bretylium tosylate on hand blood flow. Clin Sci. 1961 Oct;21:151–155. [PubMed] [Google Scholar]
  7. GAFFNEY T. E. Effect of guanethidine and bretylium on the dog heart-lung preparation. Circ Res. 1961 Jan;9:83–88. doi: 10.1161/01.res.9.1.83. [DOI] [PubMed] [Google Scholar]
  8. GILLIS C. N., NASH C. W. The initial pressor actions of bretylium tosylate and guanethidine sulfate and their relation to release of catecholamines. J Pharmacol Exp Ther. 1961 Oct;134:1–7. [PubMed] [Google Scholar]
  9. GILMORE J. P., SIEGEL J. H. Mechanism of the myocardial effects of bretylium. Circ Res. 1962 Mar;10:347–353. doi: 10.1161/01.res.10.3.347. [DOI] [PubMed] [Google Scholar]
  10. GREENFIELD A. D. A simple water filled plethysmograph for the hand or forearm with temperature control. J Physiol. 1954 Mar 29;123(3):62P–64P. [PubMed] [Google Scholar]
  11. HODGE R. L., McPHIE J. M. Acquired tolerance to bretylium tosylate ("darenthin") in the treatment of hypertension. Med J Aust. 1960 Jul 30;47(2):169–172. doi: 10.5694/j.1326-5377.1960.tb87096.x. [DOI] [PubMed] [Google Scholar]
  12. HODGE R. L., WHELAN R. F. Effect of hexamethonium on the vascular response to noradrenaline in man. Br J Pharmacol Chemother. 1962 Apr;18:331–336. doi: 10.1111/j.1476-5381.1962.tb01413.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. LEISHMAN A. W., MATTHEWS H. L., SMITH A. J. Further experience with guanethidine. Lancet. 1961 Jul 1;2(7192):4–7. doi: 10.1016/s0140-6736(61)92702-7. [DOI] [PubMed] [Google Scholar]
  14. NAKAMURA K., SHIMAMOTO K. The effects of reserpine on the responses of the nictitating membrane in the cat. Jpn J Pharmacol. 1960 Mar;9:150–158. doi: 10.1254/jjp.9.150. [DOI] [PubMed] [Google Scholar]
  15. PAGE I. H., DUSTAN H. P. A new, potent antihypertensive drug: preliminary study of [2-(octahydro-1-azocinyl)-ethyl]-guanidine sulfate (guanethidine). J Am Med Assoc. 1959 Jul 11;170(11):1265–1271. doi: 10.1001/jama.1959.03010110013003. [DOI] [PubMed] [Google Scholar]
  16. SKINNER S. L., WHELAN R. F. The circulation in forearm skin and muscle during adrenaline infusions. Aust J Exp Biol Med Sci. 1962 Apr;40:163–172. doi: 10.1038/icb.1962.19. [DOI] [PubMed] [Google Scholar]
  17. WHELAN R. F., DE LA LANDE I. S. Action of adrenaline on limb blood vessels. Br Med Bull. 1963 May;19:125–131. doi: 10.1093/oxfordjournals.bmb.a070030. [DOI] [PubMed] [Google Scholar]

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