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. 1963 Dec;21(3):462–472. doi: 10.1111/j.1476-5381.1963.tb02014.x

The effects of pronethalol, dichloroisoprenaline and disopyramide on the toxicity to the heart of ouabain and anaesthetics

A Sekiya, E M Vaughan Williams
PMCID: PMC1703875  PMID: 14110746

Abstract

An intermittent infusion of ouabain, 4 μg during 30 sec every 1.5 min, regularly caused ventricular fibrillation in guinea-pigs. The β-receptor blocking drug, pronethalol (5 mg/kg), increased the dose of ouabain required to produce extrasystoles, completely prevented fibrillation, and significantly raised the lethal dose of ouabain. Dichloroisoprenaline had similar effects, but a dose of 15 mg/kg was required. When fibrillation had already been produced by ouabain, pronethalol (3 to 4 mg) administered slowly restored a regular rhythm, but rapid injection sometimes produced cardiac arrest. As much as 20 to 25 mg/kg of pronethalol could be given to animals deeply anaesthetized with urethane or pentobarbitone, but with light chloroform or ether anaesthesia, 5 mg/kg of pronethalol caused a large fall in blood pressure and complete heart-block.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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