Abstract
A quantitative comparison of the effects of quinidine, pronethalol and γ-di-isopropylamino-α-phenyl-α-pyrid-2-ylbutyramide (disopyramide) has been made on rabbit isolated atria. All three drugs raised the electrical threshold and reduced the contractions, the conduction velocity and the maximal frequency at which the atria would follow a stimulus. The descending order of potency was pronethalol, quinidine and disopyramide, but the range was small, pronethalol having about twice the activity of disopyramide. Both the new compounds affected intracellular potentials in the same way as quinidine, causing little change in the resting potential or duration of the action potential, but reducing the overshoot potential and slowing the rate of rise of the action potential. These results support the view that interference with depolarization is an essential feature of antifibrillatory activity.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BURN J. H. The cause of fibrillation. Br Med J. 1960 May 7;1(5183):1379–1384. doi: 10.1136/bmj.1.5183.1379. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DORNHORST A. C., ROBINSON B. F. Clinical pharmacology of a beta-adrenergic-blocking agent (Nethalide). Lancet. 1962 Aug 18;2(7251):314–316. doi: 10.1016/s0140-6736(62)90104-6. [DOI] [PubMed] [Google Scholar]
- MENDEZ C., ACEVES J., MENDEZ R. Inhibition of adrenergic cardiac acceleration by cardiac glycosides. J Pharmacol Exp Ther. 1961 Feb;131:191–198. [PubMed] [Google Scholar]
- SEKIYA A., VAUGHANWILLIAMS E. M. THE EFFECTS OF PRONETHALOL, DICHLOROISOPRENALINE AND DISOPYRAMIDE ON THE TOXICITY TO THE HEART OF OUABAIN AND ANAESTHETICS. Br J Pharmacol Chemother. 1963 Dec;21:462–472. doi: 10.1111/j.1476-5381.1963.tb02014.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Szekeres L., Williams E. M. Antifibrillatory action. J Physiol. 1962 Mar;160(3):470–482. doi: 10.1113/jphysiol.1962.sp006860. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VAUGHAN WILLIAMS E. M. The mode of action of quinidine on isolated rabbit atria interpreted from intracellular potential records. Br J Pharmacol Chemother. 1958 Sep;13(3):276–287. doi: 10.1111/j.1476-5381.1958.tb00903.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WILLIAMS E. M., SEKIYA A. Prevention of arrhythmias due to cardiac glycosides by block of sympathetic beta receptors. Lancet. 1963 Feb 23;1(7278):420–421. doi: 10.1016/s0140-6736(63)92306-7. [DOI] [PubMed] [Google Scholar]
- WILLIAMS E. M., SZEKERES L. A comparison of tests for antifibrillatory action. Br J Pharmacol Chemother. 1961 Dec;17:424–432. doi: 10.1111/j.1476-5381.1961.tb01129.x. [DOI] [PMC free article] [PubMed] [Google Scholar]