Abstract
A strip of fundus from a rat's stomach was suspended in Krebs solution containing 5-hydroxytryptamine. Movements of the muscle were recorded by means of a frontal writing lever giving a magnification of sixteen-times. The strip relaxed when isoprenaline, adrenaline or noradrenaline was added to the organ-bath in concentrations of 0.2 to 2 ng/ml. The preparation was most sensitive to isoprenaline and least sensitive to noradrenaline. The components of a mixture of two catechol amines could be assayed by superfusing the rat stomach and a chick rectum in the same stream of fluid.
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Selected References
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- BORN G. V. The relation between the tension and the high-energy phosphate content of smooth muscle. J Physiol. 1956 Mar 28;131(3):704–711. doi: 10.1113/jphysiol.1956.sp005495. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GADDUM J. H., LEMBECK F. The assay of substances from the adrenal medulla. Br J Pharmacol Chemother. 1949 Dec;4(4):401–408. doi: 10.1111/j.1476-5381.1949.tb00566.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GADDUM J. H. The technique of superfusion. Br J Pharmacol Chemother. 1953 Sep;8(3):321–326. doi: 10.1111/j.1476-5381.1953.tb00801.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gaddum J. H., Peart W. S., Vogt M. The estimation of adrenaline and allied substances in blood. J Physiol. 1949 Jun 15;108(4):467–481. doi: 10.1113/jphysiol.1949.sp004350. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MANN M., WEST G. B. The nature of hepatic and splenic sympathin. Br J Pharmacol Chemother. 1950 Jun;5(2):173–177. doi: 10.1111/j.1476-5381.1950.tb01004.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MARLEY E., PATON W. D. The output of sympathetic amines from the cat's adrenal gland in response to splanchnic nerve activity. J Physiol. 1961 Jan;155:1–27. doi: 10.1113/jphysiol.1961.sp006610. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MUSCHOLL E., VOGT M. The concentration of adrenaline in the plasma of rabbits treated with reserpine. Br J Pharmacol Chemother. 1957 Dec;12(4):532–535. doi: 10.1111/j.1476-5381.1957.tb00178.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VANE J. R. A sensitive method for the assay of 5-hydroxytryptamine. Br J Pharmacol Chemother. 1957 Sep;12(3):344–349. doi: 10.1111/j.1476-5381.1957.tb00146.x. [DOI] [PMC free article] [PubMed] [Google Scholar]