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. 1964 Aug;23(1):184–200. doi: 10.1111/j.1476-5381.1964.tb01578.x

The effects of adrenaline and other drugs affecting carbohydrate metabolism on contractions of the rat diaphragm

W C Bowman, C Raper
PMCID: PMC1703966  PMID: 14208194

Abstract

The ability of several drugs to restore directly elicited twitches of the rat diaphragm depressed by excess potassium chloride has been studied. The drugs found to be effective were sympathomimetic amines, insulin, glucagon, caffeine, theophylline, calcium chloride and hexosephosphates. The effects of the sympathomimetic amines and glucagon were blocked by β-receptor blocking agents. Phloridzin blocked the effect of insulin and depressed that of glucagon. The increase in twitch tension still occurred under anaerobic conditions and was not abolished by the glycolytic inhibitor, iodoacetate. All of the effective drugs are known to affect carbohydrate metabolism and the suggestion by Ellis (1955) that the effect on contractions may be a result of increased intracellular hexosephosphate levels is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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