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. 1964 Apr;22(2):228–237. doi: 10.1111/j.1476-5381.1964.tb02028.x

The respiratory action of dichlorphenamide

D Doyle, E A Harris, K B Slawson
PMCID: PMC1703982  PMID: 14190458

Abstract

The action of dichlorphenamide has been investigated in three healthy subjects. After this drug had been given, ventilation increased while alveolar and oxygenated mixed venous Pco2 both fell. The magnitude of these changes was closely related to the degree of acidosis produced by the drug. The effect of intravenous acetazolamide, tested in one subject, was qualitatively similar to that of orally administered dichlorphenamide. Respiratory responses to carbon dioxide were studied in two of the subjects and in one of them the metabolic acidosis was sufficient to account for the short-term effect of dichlorphenamide on respiration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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