Skip to main content
British Journal of Pharmacology and Chemotherapy logoLink to British Journal of Pharmacology and Chemotherapy
. 1965 Feb;24(1):1–13. doi: 10.1111/j.1476-5381.1965.tb02075.x

The mechanism of action of mercurial diuretics in rats; the metabolism of 203hg-labelled chlormerodrin

T W Clarkson, A Rothstein, R Sutherland
PMCID: PMC1704042  PMID: 14301996

Full text

PDF
1

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BICKERS J. N., BRESLER E. H., WEINBERGER R. The acute effect of an organic mercurial on the rat kidney: a histochemical study. J Pharmacol Exp Ther. 1960 Mar;128:283–288. [PubMed] [Google Scholar]
  2. BORGHGRAEF R. R., PITTS R. F. The distribution of chlormerodrin (neohydrin) in tissues of the rat and dog. J Clin Invest. 1956 Jan;35(1):31–37. doi: 10.1172/JCI103249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BRUNNER H. [Renal water and electrolyte excretion of thirsty rats within 32 hours after a single intravenous dose of chlormerodrin or mersalyl]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1959;236:521–539. [PubMed] [Google Scholar]
  4. Bartram E. A. EXPERIMENTAL OBSERVATIONS ON THE EFFECT OF VARIOUS DIURETICS WHEN INJECTED DIRECTLY INTO ONE RENAL ARTERY OF THE DOG. J Clin Invest. 1932 Nov;11(6):1197–1219. doi: 10.1172/JCI100472. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CAMPBELL D. E. Modification by bromcresol green or probenecid of the excretion and diuretic effect of three mercurial diuretics, Diurgin, chlormerodrin and mercumatilin. Acta Pharmacol Toxicol (Copenh) 1960;17:213–232. doi: 10.1111/j.1600-0773.1960.tb01835.x. [DOI] [PubMed] [Google Scholar]
  6. CECIL R., McPHEE J. R. A kinetic study of the reactions on some disulphides with sodium sulphite. Biochem J. 1955 Jul;60(3):496–506. doi: 10.1042/bj0600496. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. ELLMAN G. L. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959 May;82(1):70–77. doi: 10.1016/0003-9861(59)90090-6. [DOI] [PubMed] [Google Scholar]
  8. FARAH A., KRUSE R. The relation of mercurial diuresis to cellular protein-bound sulfhydryl changes in renal cells. J Pharmacol Exp Ther. 1960 Sep;130:13–19. [PubMed] [Google Scholar]
  9. GAGE J. C. The distribution and excretion of inhaled mercury vapour. Br J Ind Med. 1961 Oct;18:287–294. doi: 10.1136/oem.18.4.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. KESSLER R. H., LOZANO R., PITTS R. F. Studies on structure-diuretic activity relationships of organic compounds of mercury. J Clin Invest. 1957 May;36(5):656–668. doi: 10.1172/JCI103466. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. LIGHT A. E. Diuretic activity of various compounds as determined by urinary excretion studies in rats. J Am Pharm Assoc Am Pharm Assoc. 1959 Jun;48(6):335–345. doi: 10.1002/jps.3030480612. [DOI] [PubMed] [Google Scholar]
  12. MILLER T. B., FARAH A. E. On the mechanism of the inhibition of mercurial diuresis by p-chloromercuribenzoic acid. J Pharmacol Exp Ther. 1962 Apr;136:10–19. [PubMed] [Google Scholar]
  13. MUDGE G. H., WEINER I. M. The mechanism of action of mercurial and xanthine diuretics. Ann N Y Acad Sci. 1958 Feb 3;71(4):344–354. doi: 10.1111/j.1749-6632.1958.tb46761.x. [DOI] [PubMed] [Google Scholar]
  14. SANABRIA A. Ultrastructural changes produced in the rat kidney by a mercurial diuretic (meralluride). Br J Pharmacol Chemother. 1963 Apr;20:352–361. doi: 10.1111/j.1476-5381.1963.tb01474.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. WEINER I. M., GARLID K., SAPIR D., MUDGE G. H. The effect of dimercaprol (BAL) on the renal excretion of mercurials. J Pharmacol Exp Ther. 1959 Dec;127:325–331. [PubMed] [Google Scholar]
  16. WEINER I. M., LEVY R. I., MUDGE G. H. Studies on mercurial diureis: renal excretion, acid stability and structure-activity relationships of organic mercurials. J Pharmacol Exp Ther. 1962 Oct;138:96–112. [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology and Chemotherapy are provided here courtesy of The British Pharmacological Society

RESOURCES