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. 1964 Oct;23(2):313–329. doi: 10.1111/j.1476-5381.1964.tb01589.x

The excitation and depression of mammalian cortical neurones by amino acids

J M Crawford, D R Curtis
PMCID: PMC1704095  PMID: 14228133

Abstract

Amino acids related to L-glutamic and γ-amino-n-butyric acid have been administered electrophoretically, and by pressure ejection, into the extraneuronal environment of single neurones in the pericruciate cortex of cats anaesthetized with allobarbitone or allobarbitone-urethane. Acidic amino acids related to glutamic acid, particularly N-methyl-D-aspartic acid, excited cortical neurones. Neutral amino acids related to γ-amino-n-butyric acid, particularly 3-amino-1-propanesulphonic acid, depressed cortical neurones. Some of the depressants blocked the antidromic invasion of Betz cells by pyramidal volleys. There are no essential differences between the sensitivities of cortical and spinal neurones towards locally administered amino acids. A transmitter function of such amino acids within the mammalian central nervous system is considered unlikely.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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