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. 1996 Sep;3(5):616–619. doi: 10.1128/cdli.3.5.616-619.1996

Selective gamma-chain T-cell receptor gene rearrangements in a patient with Omenn's syndrome: absence of V-II subgroup (V gamma 9) transcripts.

G Mathioudakis 1, R A Good 1, Y Chernajovsky 1, N K Day 1, C D Platsoucas 1
PMCID: PMC170420  PMID: 8877149

Abstract

Only gamma-chain T-cell receptor transcripts utilizing V-1 subgroup gene segments were found in peripheral blood lymphocytes from a patient with Omenn's syndrome. gamma-Chain T-cell receptor transcripts utilizing the V gamma 9 (V-II subgroup) gene segment were absent in peripheral blood lymphocytes from this patient. V gamma 9 J gamma 1.2 C gamma 1 rearrangements are those primarily found in peripheral blood lymphocytes (70 to 85%) from normal donors.

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Selected References

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