Skip to main content
Applied and Environmental Microbiology logoLink to Applied and Environmental Microbiology
. 1976 Dec;32(6):753–756. doi: 10.1128/aem.32.6.753-756.1976

Effect of zinc on adenine nucleotide pools in relation to aflatoxin biosynthesis in Aspergillus parasiticus.

S K Gupta, K K Maggon, T A Venkitasubramanian
PMCID: PMC170456  PMID: 1008554

Abstract

The adenylic acid systems of Aspergillus parasiticus were studied in zinc-replete and zinc-deficient media. The adenosine 5'-triphosphate levels of the fungus were high during exponential phase and low during stationary phase in zinc-replete cultures. On the other hand, the levels of adenosine 5'-diphosphate and adenosine 5'-monophosphate were low during exponential phase of growth and high during stationary phase. The adenosine 5'-triphosphate levels during exponential phase may indicate higher primary metabolic activity of the fungus. On the other hand, high adenosine 5'-monophosphate levels during stationary phase may inhibit lipid formation and may enhance aflatoxin levels. The inorganic phosphorus content was low in a zinc-replete medium throughout the growth period, thereby favoring aflatoxin biosynthesis. The energy charge during the exponential phase was high but low during the stationary phase. In general the energy charge values were lower because of high adenosine 5'-monophosphate content.

Full text

PDF
753

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chapman A. G., Fall L., Atkinson D. E. Adenylate energy charge in Escherichia coli during growth and starvation. J Bacteriol. 1971 Dec;108(3):1072–1086. doi: 10.1128/jb.108.3.1072-1086.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Detroy R. W., Ciegler A. Aflatoxin biosynthesis in Aspergillus parasiticus: effect of methionine analogs. Can J Microbiol. 1971 May;17(5):569–574. doi: 10.1139/m71-094. [DOI] [PubMed] [Google Scholar]
  3. Eigener U. Adenine nucleotide pool variations in intact Nitrobacter winogradskyi cells. Arch Microbiol. 1975 Mar 10;102(3):233–240. doi: 10.1007/BF00428373. [DOI] [PubMed] [Google Scholar]
  4. Eigener U., Bock E. Study of the regulation of oxidation and CO2 assimilation in intact Nitrobacter winogradskyi cells. Arch Microbiol. 1975 Mar 10;102(3):241–246. doi: 10.1007/BF00428374. [DOI] [PubMed] [Google Scholar]
  5. Forrest W. W. Adenosine triphosphate pool during the growth cycle in Streptococcus faecalis. J Bacteriol. 1965 Oct;90(4):1013–1018. doi: 10.1128/jb.90.4.1013-1018.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gentry M. J., Smith D. K., Schnute S. F., Werber S. L., Weinberg E. D. Pseudomonas culture longevity: control by phosphate. Microbios. 1971 Dec;4(15):205–215. [PubMed] [Google Scholar]
  7. Holzer H. Some aspects of regulation of metabolism by ATP. Adv Enzyme Regul. 1970;8:85–97. doi: 10.1016/0065-2571(70)90010-5. [DOI] [PubMed] [Google Scholar]
  8. Janglová Z., Suchý J., Vanek Z. Regulation of biosynthesis of secondary metabolites. VII. Intracellular adenosine-5'-triphosphate concentration in Streptomyces aureofaciens. Folia Microbiol (Praha) 1969;14(3):208–210. doi: 10.1007/BF02872780. [DOI] [PubMed] [Google Scholar]
  9. Reddy T. V., Viswanathan L., Venkitasubramanian T. A. Thin-layer chromatography of aflatoxins. Anal Biochem. 1970 Dec;38(2):568–571. doi: 10.1016/0003-2697(70)90487-2. [DOI] [PubMed] [Google Scholar]

Articles from Applied and Environmental Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES