Skip to main content
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1980 Aug 9;123(3):181–184.

Hepatitis non-A, non-B.

C V Feinman, B Berris, J C Sinclair, D Wrobel
PMCID: PMC1704713  PMID: 6790149

Abstract

Evidence for the existence of hepatitis non-A, non-B includes epidemiologic data and results of transmission studies indicating the presence of hepatitis that could not be explained by known causative agents. The diagnosis is suggested in patients who have multiple episodes of acute hepatitis or who contract hepatitis after transfusion, hemodialysis or drug abuse. Sporadic cases are common. Three such cases are described to illustrate that the disease is clinically indistinguishable from hepatitis A or B. The diagnosis is based on the absence of serologic markers of hepatitis A and B and of infection by Epstein-Barr virus and cytomegalovirus, or on serologic evidence of previous infection with hepatitis A and B.

Full text

PDF
181

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alter H. J., Holland P. V., Morrow A. G., Purcell R. H., Feinstone S. M., Moritsugu Y. Clinical and serological analysis of transfusion-associated hepatitis. Lancet. 1975 Nov 1;2(7940):838–841. doi: 10.1016/s0140-6736(75)90234-2. [DOI] [PubMed] [Google Scholar]
  2. Alter H. J., Holland P. V., Purcell R. H. The emerging pattern of post-transfusion hepatitis. Am J Med Sci. 1975 Sep-Oct;270(2):329–334. doi: 10.1097/00000441-197509000-00014. [DOI] [PubMed] [Google Scholar]
  3. Alter H. J., Purcell R. H., Holland P. V., Popper H. Transmissible agent in non-A, non-B hepatitis. Lancet. 1978 Mar 4;1(8062):459–463. doi: 10.1016/s0140-6736(78)90131-9. [DOI] [PubMed] [Google Scholar]
  4. Craske J., Spooner R. J., Vandervelde E. M. Evidence for existence of at least two types of factor-VIII-associated non-B transfusion hepatitis. Lancet. 1978 Nov 11;2(8098):1051–1052. doi: 10.1016/s0140-6736(78)92374-7. [DOI] [PubMed] [Google Scholar]
  5. Dienstag J. L., Bhan A. K., Alter H. J., Feinstone S. M., Purcell R. H. Circulating immune complexes in non-A, non-B hepatitis. Possible masking of viral antigen. Lancet. 1979 Jun 16;1(8129):1265–1267. doi: 10.1016/s0140-6736(79)92228-1. [DOI] [PubMed] [Google Scholar]
  6. Feinstone S. M., Kapikian A. Z., Purcell R. H., Alter H. J., Holland P. V. Transfusion-associated hepatitis not due to viral hepatitis type A or B. N Engl J Med. 1975 Apr 10;292(15):767–770. doi: 10.1056/NEJM197504102921502. [DOI] [PubMed] [Google Scholar]
  7. Feinstone S. M., Purcell R. H. Non-A, non-B hepatitis. Annu Rev Med. 1978;29:359–366. doi: 10.1146/annurev.me.29.020178.002043. [DOI] [PubMed] [Google Scholar]
  8. Galbraith R. M., Eddleston A. L., Portmann B., Williams R., Gower P. E. Chronic liver disease developing after outbreak of HBsAG-negative hepatitis in haemodialysis unit. Lancet. 1975 Nov 8;2(7941):886–890. doi: 10.1016/s0140-6736(75)92126-1. [DOI] [PubMed] [Google Scholar]
  9. HAVENS W. P., Jr Viral hepatitis: multiple attacks in a narcotic addict. Ann Intern Med. 1956 Jan;44(1):199–203. doi: 10.7326/0003-4819-44-1-199. [DOI] [PubMed] [Google Scholar]
  10. Hoofnagle J. H., Gerety R. J., Tabor E., Feinstone S. M., Barker L. F., Purcell R. H. Transmission of non-A, non-B hepatitis. Ann Intern Med. 1977 Jul;87(1):14–20. doi: 10.7326/0003-4819-87-1-14. [DOI] [PubMed] [Google Scholar]
  11. Knodell R. G., Conrad M. E., Dienstag J. L., Bell C. J. Etiological spectrum of post-transfusion hepatitis. Gastroenterology. 1975 Dec;69(6):1278–1285. [PubMed] [Google Scholar]
  12. Knodell R. G., Conrad M. E., Ishak K. G. Development of chronic liver disease after acute non-A, non-B post-transfusion hepatitis. Role of gamma-globulin prophylaxis in its prevention. Gastroenterology. 1977 May;72(5 Pt 1):902–909. [PubMed] [Google Scholar]
  13. Krugman S., Giles J. P., Hammond J. Infectious hepatitis. Evidence for two distinctive clinical, epidemiological, and immunological types of infection. JAMA. 1967 May 1;200(5):365–373. doi: 10.1001/jama.200.5.365. [DOI] [PubMed] [Google Scholar]
  14. Locarnini S. A., Gust I. D., Ferris A. A., Stott A. C., Wong M. L. A prospective study of acute viral hepatitis with particular reference to hepatitis A. Bull World Health Organ. 1976;54(2):199–206. [PMC free article] [PubMed] [Google Scholar]
  15. Mosley J. W., Redeker A. G., Feinstone S. M., Purcell R. H. Mutliple hepatitis viruses in multiple attacks of acute viral hepatitis. N Engl J Med. 1977 Jan 13;296(2):75–78. doi: 10.1056/NEJM197701132960204. [DOI] [PubMed] [Google Scholar]
  16. Müller R., Stephan B., Helmstedt D. Occurrence of viral hepatitis type B and type non-B in three patients. J Infect Dis. 1975 Aug;132(2):195–199. doi: 10.1093/infdis/132.2.195. [DOI] [PubMed] [Google Scholar]
  17. Prince A. M., Brotman B., Grady G. F., Kuhns W. J., Hazzi C., Levine R. W., Millian S. J. Long-incubation post-transfusion hepatitis without serological evidence of exposure to hepatitis-B virus. Lancet. 1974 Aug 3;2(7875):241–246. doi: 10.1016/s0140-6736(74)91412-3. [DOI] [PubMed] [Google Scholar]
  18. Shirachi R., Shiraishi H., Tateda A., Kikuchi K., Ishida N. Hepatitis "C" antigen in non-A, non-B post-transfusion hepatitis. Lancet. 1978 Oct 21;2(8095):853–856. doi: 10.1016/s0140-6736(78)91567-2. [DOI] [PubMed] [Google Scholar]
  19. Villarejos V. M., Visoná K. A., Eduarte C. A., Provost P. J., Hilleman M. R. Evidence for viral hepatitis other than type A or type B among persons in Costa Rica. N Engl J Med. 1975 Dec 25;293(26):1350–1352. doi: 10.1056/NEJM197512252932606. [DOI] [PubMed] [Google Scholar]
  20. Vitvitski L., Trepo C., Prince A. M., Brotman B. Detection of virus-associated antigen in serum and liver of patients with non-A non-B hepatitis. Lancet. 1979 Dec 15;2(8155):1263–1267. doi: 10.1016/s0140-6736(79)92280-3. [DOI] [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES