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. 1981 Feb 15;124(4):419-22, 425.

Reducing aluminum: an occupation possibly associated with bladder cancer.

G Thériault, L De Guire, S Cordier
PMCID: PMC1705253  PMID: 7214271

Abstract

A case-control study, undertaken to identify reasons for the exceptionally high incidence of bladder cancer among men in the Chicoutimi census division of the province of Quebec, revealed an increased risk associated with employment in the electrolysis department of an aluminum reduction plant. The estimated relative risk was 2.83 (95% confidence interval; 1.06 to 7.54). An interaction was found between such employment and cigarette smoking, resulting in a combined relative risk of 5.70 (95% confidence interval: 2.00 to 12.30). These findings suggest that employment in an aluminum reduction plant accounts for part of the excess of bladder cancer in the region studied.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armstrong B., Doll R. Bladder cancer mortality in diabetics in relation to saccharin consumption and smoking habits. Br J Prev Soc Med. 1975 Jun;29(2):73–81. doi: 10.1136/jech.29.2.73. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Benton B., Henderson B. E. Environmental exposure and bladder cancer in young males. J Natl Cancer Inst. 1973 Jul;51(1):269–270. doi: 10.1093/jnci/51.1.269. [DOI] [PubMed] [Google Scholar]
  3. Bross I. D., Tidings J. Another look at coffee drinking and cancer of the urinary bladder. Prev Med. 1973 Nov;2(3):445–451. doi: 10.1016/0091-7435(73)90040-6. [DOI] [PubMed] [Google Scholar]
  4. Clayson D. B. Editorial: Bladder carcinogenesis in rats and mice: possibility of artifacts. J Natl Cancer Inst. 1974 Jun;52(6):1685–1689. doi: 10.1093/jnci/52.6.1685. [DOI] [PubMed] [Google Scholar]
  5. Clayson D. B. Occupational bladder cancer. Prev Med. 1976 Jun;5(2):228–244. doi: 10.1016/0091-7435(76)90042-6. [DOI] [PubMed] [Google Scholar]
  6. Cole P. Coffee-drinking and cancer of the lower urinary tract. Lancet. 1971 Jun 26;1(7713):1335–1337. doi: 10.1016/s0140-6736(71)91890-3. [DOI] [PubMed] [Google Scholar]
  7. Cole P., Hoover R., Friedell G. H. Occupation and cancer of the lower urinary tract. Cancer. 1972 May;29(5):1250–1260. doi: 10.1002/1097-0142(197205)29:5<1250::aid-cncr2820290518>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  8. Cole P., Monson R. R., Haning H., Friedell G. H. Smoking and cancer f the lower urinary tract. N Engl J Med. 1971 Jan 21;284(3):129–134. doi: 10.1056/NEJM197101212840304. [DOI] [PubMed] [Google Scholar]
  9. DAVIES J. M. BLADDER TUMOURS IN THE ELECTRIC-CABLE INDUSTRY. Lancet. 1965 Jul 24;2(7404):143–146. doi: 10.1016/s0140-6736(65)90228-x. [DOI] [PubMed] [Google Scholar]
  10. Dale G. A., Smith R. B. Transitional cell carcinoma of the bladder associated with cyclophosphamide. J Urol. 1974 Nov;112(5):603–604. doi: 10.1016/s0022-5347(17)59806-7. [DOI] [PubMed] [Google Scholar]
  11. Dunham L. J., Rabson A. S., Stewart H. L., Frank A. S., Young J. L. Rates, interview, and pathology study of cancer of the urinary bladder in New Orleans, Louisiana. J Natl Cancer Inst. 1968 Sep;41(3):683–709. [PubMed] [Google Scholar]
  12. HUEPER W. C., PAYNE W. W. Carcinogenic studies on soot of coffee-roasting plants. Arch Pathol. 1960 Jun;69:716–727. [PubMed] [Google Scholar]
  13. Hawksworth G. M., Hill M. J. Bacteria and the N-nitrosation of secondary amines. Br J Cancer. 1971 Sep;25(3):520–526. doi: 10.1038/bjc.1971.66. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hicks R. M., Walters C. L., Elsebai I., Aasser A. B., Merzabani M. E., Gough T. A. Demonstration of nitrosamines in human urine: preliminary observations on a possible etiology for bladder cancer in association with chronic urinary tract infections. Proc R Soc Med. 1977 Jun;70(6):413–417. [PMC free article] [PubMed] [Google Scholar]
  15. Howe G. R., Burch J. D., Miller A. B., Morrison B., Gordon P., Weldon L., Chambers L. W., Fodor G., Winsor G. M. Artificial sweeteners and human bladder cancer. Lancet. 1977 Sep 17;2(8038):578–581. doi: 10.1016/s0140-6736(77)91428-3. [DOI] [PubMed] [Google Scholar]
  16. JEWETT H. J., EVERSOLE S. L., Jr Carcinoma of the bladder: characteristic modes of local invasion. J Urol. 1960 Apr;83:383–389. doi: 10.1016/S0022-5347(17)65723-9. [DOI] [PubMed] [Google Scholar]
  17. Kessler I. I. Non-nutritive sweeteners and human bladder cancer: preliminary findings. J Urol. 1976 Feb;115(2):143–146. doi: 10.1016/s0022-5347(17)59104-1. [DOI] [PubMed] [Google Scholar]
  18. LEVIN M. L., LILIENFELD A. M., MOORE G. E. The association of smoking with cancer of the urinary bladder in humans. AMA Arch Intern Med. 1956 Aug;98(2):129–135. doi: 10.1001/archinte.1956.00250260001001. [DOI] [PubMed] [Google Scholar]
  19. Lijinsky W., Taylor H. W. Induction of urinary bladder tumors in rats by administration nitrosomethyldodecylamine. Cancer Res. 1975 Apr;35(4):958–961. [PubMed] [Google Scholar]
  20. MORGANTI G., GIANFERRARI L., CRESSERI A., ARRIGONI G., LOVATI G. Recherches clinico-statistiques et génétiques sur les néoplasies de la vessie. Acta Genet Stat Med. 1956;6(2):306–307. [PubMed] [Google Scholar]
  21. Makhyoun N. A. Smoking and bladder cancer in Egypt. Br J Cancer. 1974 Dec;30(6):577–581. doi: 10.1038/bjc.1974.238. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. McCullough D. L., Lamma D. L., McLaughlin A. P., 3rd, Gittes R. F. Familial transitional cell carcinoma of the bladder. J Urol. 1975 May;113(5):629–635. doi: 10.1016/s0022-5347(17)59540-3. [DOI] [PubMed] [Google Scholar]
  23. Milham S., Jr Cancer mortality pattern associated with exposure to metals. Ann N Y Acad Sci. 1976;271:243–249. doi: 10.1111/j.1749-6632.1976.tb23118.x. [DOI] [PubMed] [Google Scholar]
  24. Miller A. B. The etiology of bladder cancer from the epidemiological viewpoint. Cancer Res. 1977 Aug;37(8 Pt 2):2939–2942. [PubMed] [Google Scholar]
  25. Parkash O., Kiesswetter H. The role of urine in the etiology of cancer of the urinary bladder. Urol Int. 1976;31(5):343–348. doi: 10.1159/000280070. [DOI] [PubMed] [Google Scholar]
  26. Price J. M., Biava C. G., Oser B. L., Vogin E. E., Steinfeld J., Ley H. L. Bladder tumors in rats fed cyclohexylamine or high doses of a mixture of cyclamate and saccharin. Science. 1970 Feb 20;167(3921):1131–1132. doi: 10.1126/science.167.3921.1131. [DOI] [PubMed] [Google Scholar]
  27. Rothman K. J. Synergy and antagonism in cause-effect relationships. Am J Epidemiol. 1974 Jun;99(6):385–388. doi: 10.1093/oxfordjournals.aje.a121626. [DOI] [PubMed] [Google Scholar]
  28. Rothman K., Keller A. The effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx. J Chronic Dis. 1972 Dec;25(12):711–716. doi: 10.1016/0021-9681(72)90006-9. [DOI] [PubMed] [Google Scholar]
  29. SCHWARTZ D., FLAMANT R., LELLOUCH J., DENOIX P. F. Results of a French survey on the role of tobacco, particularly inhalation, in different cancer sites. J Natl Cancer Inst. 1961 May;26:1085–1108. [PubMed] [Google Scholar]
  30. Saracci R. Asbestos and lung cancer: an analysis of the epidemiological evidence on the asbestos-smoking interaction. Int J Cancer. 1977 Sep 15;20(3):323–331. doi: 10.1002/ijc.2910200302. [DOI] [PubMed] [Google Scholar]
  31. Scharf J., Nahir M., Eidelman S., Jacobs R., Levin D. Carcinoma of the bladder with azathioprine therapy. JAMA. 1977 Jan 10;237(2):152–152. [PubMed] [Google Scholar]
  32. Staszewski J. Smoking and cancer of the urinary bladder in males in Poland. Br J Cancer. 1966 Mar;20(1):32–35. doi: 10.1038/bjc.1966.4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Stellman J. M., Hoffmann D. Occupational bladder cancer. Lancet. 1977 Sep 10;2(8037):563–564. doi: 10.1016/s0140-6736(77)90706-1. [DOI] [PubMed] [Google Scholar]
  34. Toyoshima K., Leighton J. Bladder calculi and urothelial hyperplasia with papillomatosis in the rat following insertion of chalk powder in the bladder cavity with subsequent trauma of the bladder wall. Cancer Res. 1975 Dec;35(12):3786–3791. [PubMed] [Google Scholar]
  35. Tsuchiya K., Okubo T., Ishizu S. An epidemiological study of occupational bladder tumours in the dye industry of Japan. Br J Ind Med. 1975 Aug;32(3):203–209. doi: 10.1136/oem.32.3.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Walter S. D. Calculation of attributable risks from epidemiological data. Int J Epidemiol. 1978 Jun;7(2):175–182. doi: 10.1093/ije/7.2.175. [DOI] [PubMed] [Google Scholar]
  37. Weir J. M., Dunn J. E., Jr Smoking and mortality: a prospective study. Cancer. 1970 Jan;25(1):105–112. doi: 10.1002/1097-0142(197001)25:1<105::aid-cncr2820250115>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  38. Wigle D. T. Bladder cancer: Possible new high-risk occupation. Lancet. 1977 Jul 9;2(8028):83–84. doi: 10.1016/s0140-6736(77)90079-4. [DOI] [PubMed] [Google Scholar]

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