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. 1997 Jul;4(4):393–399. doi: 10.1128/cdli.4.4.393-399.1997

Clinical, bacteriological, and serological aspects of Klebsiella infections and their spondylarthropathic sequelae.

H Sahly 1, R Podschun 1
PMCID: PMC170539  PMID: 9220153

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Selected References

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  1. Arbeit R. D., Arthur M., Dunn R., Kim C., Selander R. K., Goldstein R. Resolution of recent evolutionary divergence among Escherichia coli from related lineages: the application of pulsed field electrophoresis to molecular epidemiology. J Infect Dis. 1990 Feb;161(2):230–235. doi: 10.1093/infdis/161.2.230. [DOI] [PubMed] [Google Scholar]
  2. Athamna A., Ofek I., Keisari Y., Markowitz S., Dutton G. G., Sharon N. Lectinophagocytosis of encapsulated Klebsiella pneumoniae mediated by surface lectins of guinea pig alveolar macrophages and human monocyte-derived macrophages. Infect Immun. 1991 May;59(5):1673–1682. doi: 10.1128/iai.59.5.1673-1682.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Avakian H., Welsh J., Ebringer A., Entwistle C. C. Ankylosing spondylitis, HLA-B27 and Klebsiella. II. Cross-reactivity studies with human tissue typing sera. Br J Exp Pathol. 1980 Feb;61(1):92–96. [PMC free article] [PubMed] [Google Scholar]
  4. Ball J. The enthesopathy of ankylosing spondylitis. Br J Rheumatol. 1983 Nov;22(4 Suppl 2):25–28. doi: 10.1093/rheumatology/xxii.suppl_2.25. [DOI] [PubMed] [Google Scholar]
  5. Bauernfeind A., Rosenthal E., Eberlein E., Holley M., Schweighart S. Spread of Klebsiella pneumoniae producing SHV-5 beta-lactamase among hospitalized patients. Infection. 1993 Jan-Feb;21(1):18–22. doi: 10.1007/BF01739303. [DOI] [PubMed] [Google Scholar]
  6. Benjamin R., Parham P. Guilt by association: HLA-B27 and ankylosing spondylitis. Immunol Today. 1990 Apr;11(4):137–142. doi: 10.1016/0167-5699(90)90051-a. [DOI] [PubMed] [Google Scholar]
  7. Bennet R., Eriksson M., Melen B., Zetterström R. Changes in the incidence and spectrum of neonatal septicemia during a fifteen-year period. Acta Paediatr Scand. 1985 Sep;74(5):687–690. doi: 10.1111/j.1651-2227.1985.tb10014.x. [DOI] [PubMed] [Google Scholar]
  8. Beukelman C. J., Quarles van Ufford H. C., van Bree F. P., Aerts P. C., Nieuwenhoff C., Reerink G., van Leeuwen A., van Dijk H. Trial and error in producing ankylosing-spondylitis-selective antisera according to Andrew Geczy. Scand J Rheumatol Suppl. 1990;87:74–80. doi: 10.3109/03009749009097061. [DOI] [PubMed] [Google Scholar]
  9. Bingen E. H., Desjardins P., Arlet G., Bourgeois F., Mariani-Kurkdjian P., Lambert-Zechovsky N. Y., Denamur E., Philippon A., Elion J. Molecular epidemiology of plasmid spread among extended broad-spectrum beta-lactamase-producing Klebsiella pneumoniae isolates in a pediatric hospital. J Clin Microbiol. 1993 Feb;31(2):179–184. doi: 10.1128/jcm.31.2.179-184.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Bryan C. S., Hornung C. A., Reynolds K. L., Brenner E. R. Endemic bacteremia in Columbia, South Carolina. Am J Epidemiol. 1986 Jan;123(1):113–127. doi: 10.1093/oxfordjournals.aje.a114205. [DOI] [PubMed] [Google Scholar]
  11. Bryan C. S., Reynolds K. L., Brenner E. R. Analysis of 1,186 episodes of gram-negative bacteremia in non-university hospitals: the effects of antimicrobial therapy. Rev Infect Dis. 1983 Jul-Aug;5(4):629–638. doi: 10.1093/clinids/5.4.629. [DOI] [PubMed] [Google Scholar]
  12. Burwen D. R., Banerjee S. N., Gaynes R. P. Ceftazidime resistance among selected nosocomial gram-negative bacilli in the United States. National Nosocomial Infections Surveillance System. J Infect Dis. 1994 Dec;170(6):1622–1625. doi: 10.1093/infdis/170.6.1622. [DOI] [PubMed] [Google Scholar]
  13. Caffrey M. F., James D. C. Human lymphocyte antigen association in ankylosing spondylitis. Nature. 1973 Mar 9;242(5393):121–121. doi: 10.1038/242121a0. [DOI] [PubMed] [Google Scholar]
  14. Calin A., Marder A., Becks E., Burns T. Genetic differences between B27 positive patients with ankylosing spondylitis and B27 positive healthy controls. Arthritis Rheum. 1983 Dec;26(12):1460–1464. doi: 10.1002/art.1780261207. [DOI] [PubMed] [Google Scholar]
  15. Cameron F. H., Russell P. J., Sullivan J., Geczy A. F. Is a Klebsiella plasmid involved in the aetiology of Ankylosing Spondylitis in HLA-B27-positive individuals? Mol Immunol. 1983 May;20(5):563–566. doi: 10.1016/0161-5890(83)90095-0. [DOI] [PubMed] [Google Scholar]
  16. Carpenter J. L. Klebsiella pulmonary infections: occurrence at one medical center and review. Rev Infect Dis. 1990 Jul-Aug;12(4):672–682. doi: 10.1093/clinids/12.4.672. [DOI] [PubMed] [Google Scholar]
  17. Choo S. Y., St John T., Orr H. T., Hansen J. A. Molecular analysis of the variant alloantigen HLA-B27d (HLA-B*2703) identifies a unique single amino acid substitution. Hum Immunol. 1988 Mar;21(3):209–219. doi: 10.1016/0198-8859(88)90072-9. [DOI] [PubMed] [Google Scholar]
  18. Christensen S. C., Korner B. An endemic caused by multiresistant klebsiella in an urological unit. Scand J Urol Nephrol. 1972;6(3):232–238. doi: 10.3109/00365597209132093. [DOI] [PubMed] [Google Scholar]
  19. Coovadia Y. M., Johnson A. P., Bhana R. H., Hutchinson G. R., George R. C., Hafferjee I. E. Multiresistant Klebsiella pneumoniae in a neonatal nursery: the importance of maintenance of infection control policies and procedures in the prevention of outbreaks. J Hosp Infect. 1992 Nov;22(3):197–205. doi: 10.1016/0195-6701(92)90044-m. [DOI] [PubMed] [Google Scholar]
  20. Cowling P., Ebringer R., Cawdell D., Ishii M., Ebringer A. C-reactive protein, ESR, and klebsiella in ankylosing spondylitis. Ann Rheum Dis. 1980 Feb;39(1):45–49. doi: 10.1136/ard.39.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Cowling P., Ebringer R., Ebringer A. Association of inflammation with raised serum IgA in ankylosing spondylitis. Ann Rheum Dis. 1980 Dec;39(6):545–549. doi: 10.1136/ard.39.6.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Cryz S. J., Jr, Fürer E., Germanier R. Immunization against fatal experimental Klebsiella pneumoniae pneumonia. Infect Immun. 1986 Nov;54(2):403–407. doi: 10.1128/iai.54.2.403-407.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Duggan J. M., Oldfield G. S., Ghosh H. K. Septicaemia as a hospital hazard. J Hosp Infect. 1985 Dec;6(4):406–412. doi: 10.1016/0195-6701(85)90057-x. [DOI] [PubMed] [Google Scholar]
  24. Eastmond C. J., Willshaw H. E., Burgess S. E., Shinebaum R., Cooke E. M., Wright V. Frequency of faecal Klebsiella aerogenes in patients with ankylosing spondylitis and controls with respect to individual features of the disease. Ann Rheum Dis. 1980 Apr;39(2):118–123. doi: 10.1136/ard.39.2.118. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Ebringer A. Ankylosing spondylitis is caused by Klebsiella. Evidence from immunogenetic, microbiologic, and serologic studies. Rheum Dis Clin North Am. 1992 Feb;18(1):105–121. [PubMed] [Google Scholar]
  26. Ebringer A., Wilson C. The use of a low starch diet in the treatment of patients suffering from ankylosing spondylitis. Clin Rheumatol. 1996 Jan;15 (Suppl 1):62–66. doi: 10.1007/BF03342649. [DOI] [PubMed] [Google Scholar]
  27. Ebringer R. W., Cawdell D. R., Cowling P., Ebringer A. Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease. Ann Rheum Dis. 1978 Apr;37(2):146–151. doi: 10.1136/ard.37.2.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Ebringer R. W., Cawdell D. R., Cowling P., Ebringer A. Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease. Ann Rheum Dis. 1978 Apr;37(2):146–151. doi: 10.1136/ard.37.2.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Feldman C., Ross S., Mahomed A. G., Omar J., Smith C. The aetiology of severe community-acquired pneumonia and its impact on initial, empiric, antimicrobial chemotherapy. Respir Med. 1995 Mar;89(3):187–192. doi: 10.1016/0954-6111(95)90246-5. [DOI] [PubMed] [Google Scholar]
  30. Freedman R. M., Ingram D. L., Gross I., Ehrenkranz R. A., Warshaw J. B., Baltimore R. S. A half century of neonatal sepsis at Yale: 1928 to 1978. Am J Dis Child. 1981 Feb;135(2):140–144. doi: 10.1001/archpedi.1981.02130260032010. [DOI] [PubMed] [Google Scholar]
  31. García de la Torre M., Romero-Vivas J., Martínez-Beltrán J., Guerrero A., Meseguer M., Bouza E. Klebsiella bacteremia: an analysis of 100 episodes. Rev Infect Dis. 1985 Mar-Apr;7(2):143–150. doi: 10.1093/clinids/7.2.143. [DOI] [PubMed] [Google Scholar]
  32. Geczy A. F., Alexander K., Bashir H. V., Edmonds J. A factor(s) in Klebsiella culture filtrates specifically modifies an HLA-B27 associated cell-surface component. Nature. 1980 Feb 21;283(5749):782–784. doi: 10.1038/283782a0. [DOI] [PubMed] [Google Scholar]
  33. Gofton J. P., Chalmers A., Price G. E., Reeve C. E. HL-A27 and ankylosing spondylitis in B.C. Indians. J Rheumatol. 1975 Sep;2(3):314–318. [PubMed] [Google Scholar]
  34. Gofton J. P., Robinson H. S., Trueman G. E. Ankylosing spondylitis in a Canadian Indian population. Ann Rheum Dis. 1966 Nov;25(6):525–527. doi: 10.1136/ard.25.6.525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Goldstein E. J., Lewis R. P., Martin W. J., Edelstein P. H. Infections caused by Klebsiella ozaenae: a changing disease spectrum. J Clin Microbiol. 1978 Oct;8(4):413–418. doi: 10.1128/jcm.8.4.413-418.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Griffioen A. W., Rijkers G. T., Toebes E. A., Zegers B. J. The human in vitro anti-type 4 pneumococcal polysaccharide antibody response is regulated by suppressor T cells. Scand J Immunol. 1991 Aug;34(2):229–236. doi: 10.1111/j.1365-3083.1991.tb01541.x. [DOI] [PubMed] [Google Scholar]
  37. Gross W. L., Rucks A. Klebsiella pneumoniae stimulate highly purified human blood B cells to mature into plaque forming cells without prior proliferation. Clin Exp Immunol. 1983 May;52(2):372–380. [PMC free article] [PubMed] [Google Scholar]
  38. Gür D., Pitt T. L., Hall L. M., Akalin H. E., Livermore D. M. Diversity of klebsiellae with extended-spectrum beta-lactamases at a Turkish university hospital. J Hosp Infect. 1992 Oct;22(2):163–167. doi: 10.1016/0195-6701(92)90101-q. [DOI] [PubMed] [Google Scholar]
  39. Hart C. A. Klebsiellae and neonates. J Hosp Infect. 1993 Feb;23(2):83–86. doi: 10.1016/0195-6701(93)90013-p. [DOI] [PubMed] [Google Scholar]
  40. Held T. K., Trautmann M., Mielke M. E., Neudeck H., Cryz S. J., Jr, Cross A. S. Monoclonal antibody against Klebsiella capsular polysaccharide reduces severity and hematogenic spread of experimental Klebsiella pneumoniae pneumonia. Infect Immun. 1992 May;60(5):1771–1778. doi: 10.1128/iai.60.5.1771-1778.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Hermann E., Sucké B., Droste U., Meyer zum Büschenfelde K. H. Klebsiella pneumoniae-reactive T cells in blood and synovial fluid of patients with ankylosing spondylitis. Comparison with HLA-B27+ healthy control subjects in a limiting dilution study and determination of the specificity of synovial fluid T cell clones. Arthritis Rheum. 1995 Sep;38(9):1277–1282. doi: 10.1002/art.1780380916. [DOI] [PubMed] [Google Scholar]
  42. Hermann E., Yu D. T., Meyer zum Büschenfelde K. H., Fleischer B. HLA-B27-restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis. Lancet. 1993 Sep 11;342(8872):646–650. doi: 10.1016/0140-6736(93)91760-j. [DOI] [PubMed] [Google Scholar]
  43. Hill A. V., Allsopp C. E., Kwiatkowski D., Anstey N. M., Greenwood B. M., McMichael A. J. HLA class I typing by PCR: HLA-B27 and an African B27 subtype. Lancet. 1991 Mar 16;337(8742):640–642. doi: 10.1016/0140-6736(91)92452-8. [DOI] [PubMed] [Google Scholar]
  44. Hunter T., Harding G. K., Kaprove R. E., Schroeder M. L. Fecal carriage of various Klebsiella and Enterobacter species in patients with active ankylosing spondylitis. Arthritis Rheum. 1981 Jan;24(1):106–108. doi: 10.1002/art.1780240122. [DOI] [PubMed] [Google Scholar]
  45. Johnson A. P., Weinbren M. J., Ayling-Smith B., Du Bois S. K., Amyes S. G., George R. C. Outbreak of infection in two UK hospitals caused by a strain of Klebsiella pneumoniae resistant to cefotaxime and ceftazidime. J Hosp Infect. 1992 Feb;20(2):97–103. doi: 10.1016/0195-6701(92)90111-x. [DOI] [PubMed] [Google Scholar]
  46. Jong G. M., Hsiue T. R., Chen C. R., Chang H. Y., Chen C. W. Rapidly fatal outcome of bacteremic Klebsiella pneumoniae pneumonia in alcoholics. Chest. 1995 Jan;107(1):214–217. doi: 10.1378/chest.107.1.214. [DOI] [PubMed] [Google Scholar]
  47. Khan M. A. HLA-B27 and its subtypes in world populations. Curr Opin Rheumatol. 1995 Jul;7(4):263–269. doi: 10.1097/00002281-199507000-00001. [DOI] [PubMed] [Google Scholar]
  48. Kühn I., Ayling-Smith B., Tullus K., Burman L. G. The use of colonization rate and epidemic index as tools to illustrate the epidemiology of faecal Enterobacteriaceae strains in Swedish neonatal wards. J Hosp Infect. 1993 Apr;23(4):287–297. doi: 10.1016/0195-6701(93)90146-q. [DOI] [PubMed] [Google Scholar]
  49. Leirisalo-Repo M. Inflammation in HLA-B27-associated diseases. Scand J Rheumatol Suppl. 1990;87:140–147. doi: 10.3109/03009749009097076. [DOI] [PubMed] [Google Scholar]
  50. Leirisalo M., Repo H., Tiilikainen A., Kosunen T. U., Laitinen O. Chemotaxis in yersinia arthritis. HLA-B27 positive neutrophils show high stimulated motility in vitro. Arthritis Rheum. 1980 Sep;23(9):1036–1044. doi: 10.1002/art.1780230911. [DOI] [PubMed] [Google Scholar]
  51. López de Castro J. A. HLA-B27 and HLA-A2 subtypes: structure, evolution and function. Immunol Today. 1989 Jul;10(7):239–246. doi: 10.1016/0167-5699(89)90261-2. [DOI] [PubMed] [Google Scholar]
  52. Medeiros A. A. Nosocomial outbreaks of multiresistant bacteria: extended-spectrum beta-lactamases have arrived in North America. Ann Intern Med. 1993 Sep 1;119(5):428–430. doi: 10.7326/0003-4819-119-5-199309010-00015. [DOI] [PubMed] [Google Scholar]
  53. Milligan G. N., Braley-Mullen H. Regulation of IgG responses by helper and suppressor T cells activated by pneumococcal capsular polysaccharides. Cell Immunol. 1989 Mar;119(1):222–232. doi: 10.1016/0008-8749(89)90238-4. [DOI] [PubMed] [Google Scholar]
  54. Montgomerie J. Z. Epidemiology of Klebsiella and hospital-associated infections. Rev Infect Dis. 1979 Sep-Oct;1(5):736–753. doi: 10.1093/clinids/1.5.736. [DOI] [PubMed] [Google Scholar]
  55. Morgan M. E., Hart C. A., Cooke R. W. Klebsiella infection in a neonatal intensive care unit: role of bacteriological surveillance. J Hosp Infect. 1984 Dec;5(4):377–385. doi: 10.1016/0195-6701(84)90005-7. [DOI] [PubMed] [Google Scholar]
  56. Mori M., Ohta M., Agata N., Kido N., Arakawa Y., Ito H., Komatsu T., Kato N. Identification of species and capsular types of Klebsiella clinical isolates, with special reference to Klebsiella planticola. Microbiol Immunol. 1989;33(11):887–895. doi: 10.1111/j.1348-0421.1989.tb00976.x. [DOI] [PubMed] [Google Scholar]
  57. Mäki-Ikola O., Lehtinen K., Nissilä M., Granfors K. IgM, IgA and IgG class serum antibodies against Klebsiella pneumoniae and Escherichia coli lipopolysaccharides in patients with ankylosing spondylitis. Br J Rheumatol. 1994 Nov;33(11):1025–1029. doi: 10.1093/rheumatology/33.11.1025. [DOI] [PubMed] [Google Scholar]
  58. Mäki-Ikola O., Nissilä M., Lehtinen K., Leirisalo-Repo M., Granfors K. IgA1 and IgA2 subclass antibodies against Klebsiella pneumoniae in the sera of patients with peripheral and axial types of ankylosing spondylitis. Ann Rheum Dis. 1995 Aug;54(8):631–635. doi: 10.1136/ard.54.8.631. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Nissilä M., Lahesmaa R., Leirisalo-Repo M., Lehtinen K., Toivanen P., Granfors K. Antibodies to Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis in ankylosing spondylitis: effect of sulfasalazine treatment. J Rheumatol. 1994 Nov;21(11):2082–2087. [PubMed] [Google Scholar]
  60. Noriega E. R., Leibowitz R. E., Richmond A. S., Rubinstein E., Schaefler S., Simberkoff M. S., Rahal J. J., Jr Nosocomial infection caused by gentamicin-resistant, streptomycin-sensitive Klebsiella. J Infect Dis. 1975 May;131 (Suppl):S45–S50. doi: 10.1093/infdis/131.supplement.s45. [DOI] [PubMed] [Google Scholar]
  61. Ofek I., Goldhar J., Keisari Y., Sharon N. Nonopsonic phagocytosis of microorganisms. Annu Rev Microbiol. 1995;49:239–276. doi: 10.1146/annurev.mi.49.100195.001323. [DOI] [PubMed] [Google Scholar]
  62. Ohlsson A., Bailey T., Takieddine F. Changing etiology and outcome of neonatal septicemia in Riyadh, Saudi Arabia. Acta Paediatr Scand. 1986 Jul;75(4):540–544. doi: 10.1111/j.1651-2227.1986.tb10246.x. [DOI] [PubMed] [Google Scholar]
  63. Pease C. T., Fordham J. N., Currey H. L. Polymorphonuclear cell motility, ankylosing spondylitis, and HLA B27. Ann Rheum Dis. 1984 Apr;43(2):279–284. doi: 10.1136/ard.43.2.279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Pittet D., Li N., Wenzel R. P. Association of secondary and polymicrobial nosocomial bloodstream infections with higher mortality. Eur J Clin Microbiol Infect Dis. 1993 Nov;12(11):813–819. doi: 10.1007/BF02000400. [DOI] [PubMed] [Google Scholar]
  65. Podschun R., Sievers D., Fischer A., Ullmann U. Serotypes, hemagglutinins, siderophore synthesis, and serum resistance of Klebsiella isolates causing human urinary tract infections. J Infect Dis. 1993 Dec;168(6):1415–1421. doi: 10.1093/infdis/168.6.1415. [DOI] [PubMed] [Google Scholar]
  66. Podschun R., Ullmann U. Isolation of Klebsiella terrigena from clinical specimens. Eur J Clin Microbiol Infect Dis. 1992 Apr;11(4):349–352. doi: 10.1007/BF01962076. [DOI] [PubMed] [Google Scholar]
  67. Reish O., Ashkenazi S., Naor N., Samra Z., Merlob P. An outbreak of multiresistant Klebsiella in a neonatal intensive care unit. J Hosp Infect. 1993 Dec;25(4):287–291. doi: 10.1016/0195-6701(93)90115-g. [DOI] [PubMed] [Google Scholar]
  68. Repo H., Leirisalo M., Kosunen T. U. Neutrophil chemotaxis under agarose: a statistical analysis and comparison of the chemotactic response of cells from different donors. J Immunol Methods. 1981;46(2):227–242. doi: 10.1016/0022-1759(81)90139-3. [DOI] [PubMed] [Google Scholar]
  69. Russell A. S., Suarez Almazor M. E. Ankylosing spondylitis is not caused by Klebsiella. Rheum Dis Clin North Am. 1992 Feb;18(1):95–104. [PubMed] [Google Scholar]
  70. Sahly H., Kekow J., Podschun R., Schaff M., Gross W. L., Ullmann U. Comparison of the antibody responses to the 77 Klebsiella capsular types in ankylosing spondylitis and various rheumatic diseases. Infect Immun. 1994 Nov;62(11):4838–4843. doi: 10.1128/iai.62.11.4838-4843.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Sahly H., Podschun R., Sass R., Bröker B., Kekow J., Gross W. L., Ullmann U. Serum antibodies to Klebsiella capsular polysaccharides in ankylosing spondylitis. Arthritis Rheum. 1994 May;37(5):754–759. doi: 10.1002/art.1780370521. [DOI] [PubMed] [Google Scholar]
  72. Schlosstein L., Terasaki P. I., Bluestone R., Pearson C. M. High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med. 1973 Apr 5;288(14):704–706. doi: 10.1056/NEJM197304052881403. [DOI] [PubMed] [Google Scholar]
  73. Schwimmbeck P. L., Yu D. T., Oldstone M. B. Autoantibodies to HLA B27 in the sera of HLA B27 patients with ankylosing spondylitis and Reiter's syndrome. Molecular mimicry with Klebsiella pneumoniae as potential mechanism of autoimmune disease. J Exp Med. 1987 Jul 1;166(1):173–181. doi: 10.1084/jem.166.1.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Seager K., Bashir H. V., Geczy A. F., Edmonds J., de Vere-Tyndall A. Evidence for a specific B27-associated cell surface marker on lymphocytes of patients with ankylosing spondylitis. Nature. 1979 Jan 4;277(5691):68–70. doi: 10.1038/277068a0. [DOI] [PubMed] [Google Scholar]
  75. Sirot D. Extended-spectrum plasmid-mediated beta-lactamases. J Antimicrob Chemother. 1995 Jul;36 (Suppl A):19–34. doi: 10.1093/jac/36.suppl_a.19. [DOI] [PubMed] [Google Scholar]
  76. Smith M. J., Hart C. A., Cooke K. W. Gentamicin-resistant Klebsiella oxytoca on a special care baby unit. Lancet. 1984 Sep 8;2(8402):586–587. doi: 10.1016/s0140-6736(84)90812-2. [DOI] [PubMed] [Google Scholar]
  77. Sprenkels S. H., Uksila J., Vainionpä R., Toivanen P., Feltkamp T. E. IgA antibodies in HLA-B27 associated acute anterior uveitis and ankylosing spondylitis. Clin Rheumatol. 1996 Jan;15 (Suppl 1):52–56. doi: 10.1007/BF03342647. [DOI] [PubMed] [Google Scholar]
  78. Sprenkels S. H., Van Kregten E., Feltkamp T. E. IgA antibodies against Klebsiella and other Gram-negative bacteria in ankylosing spondylitis and acute anterior uveitis. Clin Rheumatol. 1996 Jan;15 (Suppl 1):48–51. doi: 10.1007/BF03342646. [DOI] [PubMed] [Google Scholar]
  79. Tarkkanen A. M., Allen B. L., Williams P. H., Kauppi M., Haahtela K., Siitonen A., Orskov I., Orskov F., Clegg S., Korhonen T. K. Fimbriation, capsulation, and iron-scavenging systems of Klebsiella strains associated with human urinary tract infection. Infect Immun. 1992 Mar;60(3):1187–1192. doi: 10.1128/iai.60.3.1187-1192.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  80. Tessin I., Trollfors B., Thiringer K. Incidence and etiology of neonatal septicaemia and meningitis in western Sweden 1975-1986. Acta Paediatr Scand. 1990 Nov;79(11):1023–1030. doi: 10.1111/j.1651-2227.1990.tb11378.x. [DOI] [PubMed] [Google Scholar]
  81. Trull A. K., Ebringer R., Panayi G. S., Colthorpe D., James D. C., Ebringer A. IgA antibodies to Klebsiella pneumoniae in ankylosing spondylitis. Scand J Rheumatol. 1983;12(3):249–253. doi: 10.3109/03009748309098543. [DOI] [PubMed] [Google Scholar]
  82. Tullus K., Ayling-Smith B., Kühn I., Rabsch W., Reissbrodt R., Burman L. G. Nationwide spread of Klebsiella oxytoca K55 in Swedish neonatal special care wards. APMIS. 1992 Nov;100(11):1008–1014. [PubMed] [Google Scholar]
  83. Tullus K., Olsson-Liljequist B., Lundström G., Burman L. G. Antibiotic susceptibility of 629 bacterial blood and CSF isolates from Swedish infants and the therapeutic implications. Acta Paediatr Scand. 1991 Feb;80(2):205–212. doi: 10.1111/j.1651-2227.1991.tb11835.x. [DOI] [PubMed] [Google Scholar]
  84. Vesikari T., Isolauri E., Tuppurainen N., Renlund M., Koivisto M., Janas M., Ikonen R. S., Kero P., Heinonen K., Nyman R. Neonatal septicaemia in Finland 1981-85. Predominance of group B streptococcal infections with very early onset. Acta Paediatr Scand. 1989 Jan;78(1):44–50. doi: 10.1111/j.1651-2227.1989.tb10885.x. [DOI] [PubMed] [Google Scholar]
  85. Welsh J., Avakian H., Cowling P., Ebringer A., Wooley P., Panayi G., Ebringer R. Ankylosing spondylitis, HLA-B27 and Klebsiella. I. Cross-reactivity studies with rabbit antisera. Br J Exp Pathol. 1980 Feb;61(1):85–91. [PMC free article] [PubMed] [Google Scholar]
  86. de Vries D. D., Dekker-Saeys A. J., Gyodi E., Ivanyi P. Failure to detect cross-reacting antibodies to HLA-B27.5 and Klebsiella pneumoniae nitrogenase in sera from patients with ankylosing spondylitis and Reiter's syndrome. Scand J Rheumatol Suppl. 1990;87:72–73. doi: 10.3109/03009749009097060. [DOI] [PubMed] [Google Scholar]
  87. van Bohemen C. G., Nabbe A. J., Goei The H. S., Dekker-Saeys A. J., Zanen H. C. Antibodies to Enterobacteriaceae in ankylosing spondylitis. Scand J Rheumatol. 1986;15(2):143–147. doi: 10.3109/03009748609102080. [DOI] [PubMed] [Google Scholar]
  88. van Kregten E., Huber-Bruning O., Vandenbroucke J. P., Willers J. M. No conclusive evidence of an epidemiological relation between Klebsiella and ankylosing spondylitis. J Rheumatol. 1991 Mar;18(3):384–388. [PubMed] [Google Scholar]
  89. van der Linden S. M., Valkenburg H. A., de Jongh B. M., Cats A. The risk of developing ankylosing spondylitis in HLA-B27 positive individuals. A comparison of relatives of spondylitis patients with the general population. Arthritis Rheum. 1984 Mar;27(3):241–249. doi: 10.1002/art.1780270301. [DOI] [PubMed] [Google Scholar]

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