Abstract
Production of cyclopiazonic acid by Aspergillus flavus is reported for the first time. A procedure for its production by agitated solid substrate fermentation on red wheat is described along with the isolation procedure and physical and chemical properties of this indole derivative. The compound has been found to exert antibacterial activity.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Demain A. L., Hunt N. A., Malik V., Kobbe B., Hawkins H., Matsuo K., Wogan G. N. Improved procedure for production of cytochalasin E and tremorgenic mycotoxins by Aspergillus clavatus. Appl Environ Microbiol. 1976 Jan;31(1):138–140. doi: 10.1128/aem.31.1.138-140.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Holzapfel C. W. The isolation and structure of cyclopiazonic acid, a toxic metabolite of Penicillium cyclopium Westling. Tetrahedron. 1968 Mar;24(5):2101–2119. doi: 10.1016/0040-4020(68)88113-x. [DOI] [PubMed] [Google Scholar]
- Purchase I. F. The acute toxicity of the mycotoxin cyclopiazonic acid to rats. Toxicol Appl Pharmacol. 1971 Jan;18(1):114–123. doi: 10.1016/0041-008x(71)90320-6. [DOI] [PubMed] [Google Scholar]