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. 1997 Nov;4(6):774–777. doi: 10.1128/cdli.4.6.774-777.1997

Salmonella infection increases porcine antibacterial peptide concentrations in serum.

G Zhang 1, C R Ross 1, S S Dritz 1, J C Nietfeld 1, F Blecha 1
PMCID: PMC170657  PMID: 9384306

Abstract

PR-39 is a multifunctional neutrophil peptide involved in host defense and inflammation. To investigate the involvement of PR-39 in a Salmonella choleraesuis infection, a PR-39 enzyme immunoassay was developed. The concentrations of PR-39 in serum were 13.6 +/- 1.9 ng/ml before challenge and increased (P < 0.01) threefold by 10 to 14 days postinfection. Peripheral blood neutrophil counts paralleled the changes in the concentrations of PR-39 in serum, both returned to basal values by 4 weeks postinfection. These findings suggest that the concentrations of serum PR-39 reflect the involvement of this antibacterial peptide in the host's response to an S. choleraesuis infection.

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Selected References

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