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. 1981 Jan;37(1):1–6. doi: 10.1128/jvi.37.1.1-6.1981

Comparative study of rabies virus persistence in human and hamster cell lines.

O G Andzhaparidze, N N Bogomolova, Y S Boriskin, M S Bektemirova, I D Drynov
PMCID: PMC170975  PMID: 7218421

Abstract

Persistent infections by rabies virus in BHK-21/13S and HEp-2 cells were studied comparatively. No evidence of interferon production, selection of virus-resistant cells, or integration of the viral genome could be found. Persisting viruses replicated efficiently at 34, 36, and 40 degrees C. Both persistently infected cultures released defective interfering virus particles. A cyclical pattern of infection, which was not characteristic of the persistently infected HEp-2 system, was observed in persistently infected BHK cultures. The virus from persistently infected BHK cultures lost its virulence for mice, whereas the virus from persistently infected HEp-2 cultures retained mouse-killing capacity for more than 3 years.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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