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. 1981 Jan;37(1):488–492. doi: 10.1128/jvi.37.1.488-492.1981

Replicating, differentiated macrophages can serve as in vitro targets for transformation by avian myeloblastosis virus.

E M Durban, D Boettiger
PMCID: PMC171026  PMID: 6260997

Abstract

Pure cultures of chicken macrophages were characterized functionally and transformed by avian myeloblastosis virus. Transformed cells exhibited an altered function. The efficiency of transformation was limited by the mitotic activity of the macrophages.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BALUDA M. A., GOETZ I. E. Morphological conversion of cell cultures by avian myeloblastosis virus. Virology. 1961 Oct;15:185–199. doi: 10.1016/0042-6822(61)90234-3. [DOI] [PubMed] [Google Scholar]
  2. BALUDA M. A. Properties of cells infected with avian myeloblastosis virus. Cold Spring Harb Symp Quant Biol. 1962;27:415–425. doi: 10.1101/sqb.1962.027.001.039. [DOI] [PubMed] [Google Scholar]
  3. BEAUDREAU G. S., BECKER C., BONAR R. A., WALLBANK A. M., BEARD D., BEARD J. W. Virus of avian myeloblastosis. XIV. Neoplastic response of normal chicken bone marrow treated with the virus in tissue culture. J Natl Cancer Inst. 1960 Feb;24:395–415. [PubMed] [Google Scholar]
  4. Beug H., von Kirchbach A., Döderlein G., Conscience J. F., Graf T. Chicken hematopoietic cells transformed by seven strains of defective avian leukemia viruses display three distinct phenotypes of differentiation. Cell. 1979 Oct;18(2):375–390. doi: 10.1016/0092-8674(79)90057-6. [DOI] [PubMed] [Google Scholar]
  5. Boettiger D., Temin H. M. Light inactivation of focus formation by chicken embryo fibroblasts infected with avian sarcoma virus in the presence of 5-bromodeoxyuridine. Nature. 1970 Nov 14;228(5272):622–624. doi: 10.1038/228622a0. [DOI] [PubMed] [Google Scholar]
  6. ECKERT E. A., BEARD D., BEARD J. W., BURMESTER B. R. Dose-response relations in experimental transmission of avian erythromyeloblastic leukosis. II. Host-response to whole blood and to washed primitive cells. J Natl Cancer Inst. 1953 Apr;13(5):1167–1184. [PubMed] [Google Scholar]
  7. ECKERT E. A., BEARD D., BEARD J. W. Dose-response relations in experimental transmission of avian erythromyeloblastic leukosis. I. Host-response to the virus. J Natl Cancer Inst. 1951 Oct;12(2):447–463. [PubMed] [Google Scholar]
  8. Gazzolo L., Moscovici C., Moscovici M. G., Samarut J. Response of hemopoietic cells to avian acute leukemia viruses: effects on the differentiation of the target cells. Cell. 1979 Mar;16(3):627–638. doi: 10.1016/0092-8674(79)90036-9. [DOI] [PubMed] [Google Scholar]
  9. Gordon S., Cohn Z. Macrophage-melanocyte heterokaryons. I. Preparation and properties. J Exp Med. 1970 May 1;131(5):981–1003. doi: 10.1084/jem.131.5.981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Graf T., Beug H. Avian leukemia viruses: interaction with their target cells in vivo and in vitro. Biochim Biophys Acta. 1978 Nov 17;516(3):269–299. doi: 10.1016/0304-419x(78)90011-2. [DOI] [PubMed] [Google Scholar]
  11. Moscovici C. A quantitative assay for avian myeloblastosis virus. Proc Soc Exp Biol Med. 1967 Aug-Sep;125(4):1213–1215. doi: 10.3181/00379727-125-32316. [DOI] [PubMed] [Google Scholar]
  12. Moscovici C., Gazzolo L., Moscovici M. G. Focus assay and defectiveness of avian myeloblastosis virus. Virology. 1975 Nov;68(1):173–181. doi: 10.1016/0042-6822(75)90159-2. [DOI] [PubMed] [Google Scholar]
  13. Weiss R. A. Cell transformation induced by Rous sarcoma virus: analysis of density dependence. Virology. 1971 Nov;46(2):200–220. [PubMed] [Google Scholar]

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