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. 1981 Feb;37(2):836–839. doi: 10.1128/jvi.37.2.836-839.1981

Cytoplasmic viral DNA synthesis in exogenous infection of murine leukemia virus: effect of interferon and cycloheximide.

M Aboud, D Moldovan-Levin, S Salzberg
PMCID: PMC171073  PMID: 6163875

Abstract

Cytoplasmic viral DNA synthesis can be followed efficiently by [3H]thymidine labeling of cells exogenously infected with Moloney murine leukemia virus. Both the negative and the positive strands of viral DNA reached their maximal level in the cytoplasm at 3.5 h postinfection. Interferon treatment before infection markedly reduced the amount of viral DNA formed during the first 3.5 h, but led to a second major wave of viral DNA synthesis, peaking at 7.5 h postinfection. No such late cytoplasmic DNA synthesis occurred in the untreated control. Inhibition of protein synthesis by cycloheximide, on the other hand, stimulated cytoplasmic viral DNA synthesis during the first 3.5 h.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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