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. 1981 Mar;37(3):1090–1093. doi: 10.1128/jvi.37.3.1090-1093.1981

Association of cellular 56,000- and 32,000-molecular-weight protein with BK virus and polyoma virus t-antigens.

K Rundell, E O Major, M Lampert
PMCID: PMC171110  PMID: 6262529

Abstract

Two cellular proteins (molecular weights: 56,000 and 32,000) were specifically co-immunoprecipitated by simian virus 40 and BK virus t-antigens and by polyoma virus non-T early proteins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bouck N., Beales N., Shenk T., Berg P., di Mayorca G. New region of the simian virus 40 genome required for efficient viral transformation. Proc Natl Acad Sci U S A. 1978 May;75(5):2473–2477. doi: 10.1073/pnas.75.5.2473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Friedmann T., Doolittle R. F., Walter G. Amino acid sequence homology between polyoma and SV40 tumour antigens deduced from nucleotide sequences. Nature. 1978 Jul 20;274(5668):291–293. doi: 10.1038/274291a0. [DOI] [PubMed] [Google Scholar]
  3. Friedmann T., Esty A., LaPorte P., Deininger P. The nucleotide sequence and genome organization of the polyoma early region: extensive nucleotide and amino acid homology with SV40. Cell. 1979 Jul;17(3):715–724. doi: 10.1016/0092-8674(79)90278-2. [DOI] [PubMed] [Google Scholar]
  4. Graessmann A., Graessmann M., Tjian R., Topp W. C. Simian virus 40 small-t protein is required for loss of actin cable networks in rat cells. J Virol. 1980 Mar;33(3):1182–1191. doi: 10.1128/jvi.33.3.1182-1191.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hutchinson M. A., Hunter T., Eckhart W. Characterization of T antigens in polyoma-infected and transformed cells. Cell. 1978 Sep;15(1):65–77. doi: 10.1016/0092-8674(78)90083-1. [DOI] [PubMed] [Google Scholar]
  6. Ito Y., Brocklehurst J. R., Dulbecco R. Virus-specific proteins in the plasma membrane of cells lytically infected or transformed by pol-oma virus. Proc Natl Acad Sci U S A. 1977 Oct;74(10):4666–4670. doi: 10.1073/pnas.74.10.4666. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lania L., Griffiths M., Cooke B., Ito Y., Fried M. Untransformed rat cells containing free and integrated DNA of a polyoma nontransforming (Hr-t) mutant. Cell. 1979 Nov;18(3):793–802. doi: 10.1016/0092-8674(79)90132-6. [DOI] [PubMed] [Google Scholar]
  8. Major E. O., Di Mayorca G. Malignant transformation of BHK21 clone 13 cells by BK virus--a human papovavirus. Proc Natl Acad Sci U S A. 1973 Nov;70(11):3210–3212. doi: 10.1073/pnas.70.11.3210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Martin R. G., Setlow V. P., Edwards C. A., Vembu D. The roles of the simian virus 40 tumor antigens in transformation of Chinese hamster lung cells. Cell. 1979 Jul;17(3):635–643. doi: 10.1016/0092-8674(79)90271-x. [DOI] [PubMed] [Google Scholar]
  10. Rundell K., Hearing P., Yang Y. C. SV40 17K protein is associated with two cellular proteins. Cold Spring Harb Symp Quant Biol. 1980;44(Pt 1):211–214. doi: 10.1101/sqb.1980.044.01.024. [DOI] [PubMed] [Google Scholar]
  11. Rundell K., Tegtmeyer P., Wright P. J., Di Mayorca G. Identification of the human papovavirus T antigen and comparison with the simian virus 40 protein a. Virology. 1977 Oct 1;82(1):206–213. doi: 10.1016/0042-6822(77)90043-5. [DOI] [PubMed] [Google Scholar]
  12. Schlegel R., Benjamin T. L. Cellular alterations dependent upon the polyoma virus Hr-t function: separation of mitogenic from transforming capacities. Cell. 1978 Jul;14(3):587–599. doi: 10.1016/0092-8674(78)90244-1. [DOI] [PubMed] [Google Scholar]
  13. Simmons D. T., Chang C., Martin M. A. Multiple forms of polyoma virus tumor antigens from infected and transformed cells. J Virol. 1979 Mar;29(3):881–887. doi: 10.1128/jvi.29.3.881-887.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Simmons D. T., Takemoto K. K., Martin M. A. Relationship between the methionine tryptic peptides of simian virus 40 and BK virus tumor antigens. J Virol. 1977 Oct;24(1):319–325. doi: 10.1128/jvi.24.1.319-325.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sleigh M. J., Topp W. C., Hanich R., Sambrook J. F. Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells. Cell. 1978 May;14(1):79–88. doi: 10.1016/0092-8674(78)90303-3. [DOI] [PubMed] [Google Scholar]
  16. Soeda E., Arrand J. R., Smolar N., Griffin B. E. Sequence from early region of polyoma virus DNA containing viral replication origin and encoding small, middle and (part of) large T antigens. Cell. 1979 Jun;17(2):357–370. doi: 10.1016/0092-8674(79)90162-4. [DOI] [PubMed] [Google Scholar]
  17. Staneloni R. J., Fluck M. M., Benjamin T. L. Host range selection of transformation-defective hr-t mutants of polyoma virus. Virology. 1977 Apr;77(2):598–609. doi: 10.1016/0042-6822(77)90485-8. [DOI] [PubMed] [Google Scholar]
  18. Wright P. J., Di Mayorca G. Virion polypeptide composition of the human papovavirus BK: comparison with simian virus 40 and polyoma virus. J Virol. 1975 Apr;15(4):828–835. doi: 10.1128/jvi.15.4.828-835.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Yang Y. C., Hearing P., Rundell K. Cellular proteins associated with simian virus 40 early gene products in newly infected cells. J Virol. 1979 Oct;32(1):147–154. doi: 10.1128/jvi.32.1.147-154.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]

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